{"id":"W4417201262","doi":"10.1158/1557-3265.earlyonsetca25-c004","title":"Abstract C004: Colonic Tissue Renewal, Retinoic Acid Signaling, Early-onset CRC","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Retinoic acid; Calcitriol receptor; Retinoid X receptor gamma; Retinoid; Retinoic acid receptor; Germline mutation; Somatic cell; Retinoid X receptor; Vitamin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000244001,0.0004651687,0.0003025797,0.0007558816,0.0003700375,0.0004495264,0.0004364253,0.0008136581,0.01491502],"category_scores_gemma":[0.0002294531,0.00009911614,0.0003187532,0.0005483243,0.0004032274,0.0002517039,0.0002947904,0.0009228411,0.002333059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005779014,"about_ca_system_score_gemma":0.0005651849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135323,"about_ca_topic_score_gemma":0.001434269,"domain_scores_codex":[0.9998562,0.00002823245,0.0000115772,0.0000347184,0.00004265987,0.00002659952],"domain_scores_gemma":[0.9998338,0.00003271075,0.0000439387,0.0000077229,0.00003917893,0.00004250164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007219327,0.001194249,0.03223388,0.00504506,0.0001650753,0.006399559,0.0001862526,0.0007565187,0.6787496,0.006726862,0.04032392,0.2209997],"study_design_scores_gemma":[0.0008403827,0.006914105,0.2910137,0.0009181308,0.0006129738,0.02126367,0.0007377226,0.002826165,0.3988947,0.005798909,0.2700694,0.0001101236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7377433,0.1662127,0.007556367,0.0191625,0.003793555,0.0004538501,0.005236759,0.0006066597,0.05923424],"genre_scores_gemma":[0.8754665,0.05232679,0.005381374,0.002810455,0.001510405,0.0002916391,0.003588387,0.00004817222,0.05857624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01491502,"threshold_uncertainty_score":0.0498957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08375311066845019,"score_gpt":0.4879194193459572,"score_spread":0.404166308677507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}