{"id":"W4417201280","doi":"10.1158/1557-3265.earlyonsetca25-pr005","title":"Abstract PR005: Uncovering the Etiology of Early-Onset Gastric Cancer in Latinos Through Germline and Tumor Genomic Profiling","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Germline; Germline mutation; Cancer; Etiology; Disease; Epigenetics; Microbiome; Somatic cell; MLH1","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000397373,0.0002723057,0.0002179757,0.0008808312,0.0003638928,0.0005978788,0.0002615517,0.000276652,0.002949769],"category_scores_gemma":[0.001004278,0.0001226078,0.0003380611,0.0009497803,0.0002596559,0.0002186674,0.0005463259,0.0003226133,0.0004095907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003365634,"about_ca_system_score_gemma":0.0004588475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008013973,"about_ca_topic_score_gemma":0.007756043,"domain_scores_codex":[0.9998734,0.00002168006,0.000007457982,0.00004906301,0.0000178354,0.00003046104],"domain_scores_gemma":[0.9996966,0.00005638162,0.0001073602,0.00002667794,0.00007045161,0.00004249792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003655041,0.00006342168,0.9549879,0.0001870241,0.0001859791,0.001024918,0.000521286,0.0001700165,0.02044292,0.00029067,0.001278565,0.02048174],"study_design_scores_gemma":[0.0000327096,0.0001298686,0.9856829,0.0001179235,0.0002157183,0.001698074,0.001365898,0.0006985103,0.0029328,0.0005936808,0.006520124,0.00001187544],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898066,0.00145811,0.001450947,0.000521662,0.00002366303,0.00003871612,0.004381951,0.00006367461,0.002254609],"genre_scores_gemma":[0.9932796,0.000844356,0.001654439,0.0003406784,0.00002325898,0.00003387575,0.002770054,0.00003907502,0.001014756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008013973,"threshold_uncertainty_score":0.01593465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08547236932481178,"score_gpt":0.4635764095743373,"score_spread":0.3781040402495255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}