{"id":"W4417201283","doi":"10.1158/1557-3265.earlyonsetca25-pr004","title":"Abstract PR004: Mutational signature profiling identifies a distinct subgroup of early-onset colorectal cancer associated with younger age at diagnosis, recent birth year and specific genomic features","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"","keywords":"Colorectal cancer; Exome sequencing; Microsatellite instability; Genomics; Exome; DNA sequencing; Cancer; Cluster analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003096195,0.0002291938,0.0002974734,0.001146341,0.0002271501,0.0005062418,0.000247273,0.0002632097,0.003289182],"category_scores_gemma":[0.001293516,0.000102247,0.0003752565,0.001116743,0.0001506648,0.0001707762,0.0003851387,0.0002518936,0.0004741921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039556,"about_ca_system_score_gemma":0.0002660623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002162149,"about_ca_topic_score_gemma":0.002679205,"domain_scores_codex":[0.9997594,0.00002891709,0.00002408602,0.00009961161,0.00004830597,0.00003976786],"domain_scores_gemma":[0.9993899,0.0001208881,0.0002445638,0.0000670007,0.00007542308,0.0001022048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001000766,0.00002717952,0.9673692,0.00005840214,0.000118802,0.0004553196,0.00009170928,0.0001427409,0.02073036,0.00004610772,0.0006368563,0.009322556],"study_design_scores_gemma":[0.00000962169,0.00007582755,0.9968134,0.000005392232,0.00005894657,0.0009090584,0.00007610806,0.0002962473,0.001247713,0.00003799469,0.0004664719,0.000003228729],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973574,0.0001360375,0.0003144605,0.00003283842,0.000003100866,0.000007049948,0.001796482,0.00002423465,0.0003282128],"genre_scores_gemma":[0.9962466,0.00005349882,0.0003458718,0.00001502573,0.000005999546,0.000006315541,0.002986399,0.00001121058,0.0003289603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003289182,"threshold_uncertainty_score":0.01100343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04918273136314091,"score_gpt":0.3934973011669421,"score_spread":0.3443145698038012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}