{"id":"W4417201691","doi":"10.1158/1557-3265.earlyonsetca25-c034","title":"Abstract C034: Obesity-Linked Leptin Signaling Promotes Immune Checkpoint Expression and Tumor Cell Survival","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Leptin; Gene knockdown; Adipokine; Immune system; Immune checkpoint; Leptin receptor; Tumor progression; Downregulation and upregulation; Gene silencing; Apoptosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107258,0.0004063212,0.0003022103,0.0003067214,0.0003087517,0.0003636696,0.0002468786,0.000488311,0.008872781],"category_scores_gemma":[0.00009582441,0.0001166254,0.0004432966,0.0003105726,0.000200076,0.0002064754,0.0002264516,0.0008254868,0.002010409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004399138,"about_ca_system_score_gemma":0.0005602537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008897464,"about_ca_topic_score_gemma":0.0008529717,"domain_scores_codex":[0.9998683,0.00001151798,0.00001055815,0.00002864703,0.00003679923,0.00004414274],"domain_scores_gemma":[0.9999145,0.000007910844,0.0000194349,0.000007240882,0.00001979223,0.00003112241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001245084,0.0001109489,0.0002887362,0.0002227377,0.00001656502,0.0001168862,0.00001343456,0.00007457557,0.9918223,0.0002480713,0.0008966136,0.004944028],"study_design_scores_gemma":[0.0002772317,0.001154362,0.01107363,0.00005186085,0.00005573831,0.0005999941,0.00007561579,0.001157402,0.9689143,0.0002538379,0.01637434,0.00001173312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644136,0.01408536,0.004809091,0.001108321,0.0004195786,0.000157204,0.004320971,0.0004103313,0.01027556],"genre_scores_gemma":[0.9762943,0.003608985,0.00250063,0.0004400337,0.00007733441,0.0001795344,0.004113499,0.00008137468,0.01270434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008872781,"threshold_uncertainty_score":0.0296824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1718553186604019,"score_gpt":0.4593158004566219,"score_spread":0.28746048179622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}