{"id":"W4417201693","doi":"10.1158/1557-3265.earlyonsetca25-b003","title":"Abstract B003: Risk Factors, Clinical and Molecular Characteristics of de novo Metastatic Early Onset Colorectal Cancer","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Colorectal cancer; KRAS; Cancer; Disease; Exome sequencing; Stage (stratigraphy); Clinical significance","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003306794,0.0002939785,0.0002281264,0.0007917499,0.0003221845,0.0003830964,0.0003024259,0.0003330037,0.01180538],"category_scores_gemma":[0.001607698,0.0001058742,0.0002629127,0.001044223,0.0001286613,0.0002469019,0.0003041043,0.0004286087,0.001408176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700877,"about_ca_system_score_gemma":0.0002911246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002700869,"about_ca_topic_score_gemma":0.002711062,"domain_scores_codex":[0.9998295,0.0000341031,0.00001917855,0.00004259998,0.00004480511,0.00002976722],"domain_scores_gemma":[0.999082,0.000161807,0.0002537632,0.00004387024,0.0001593296,0.000299206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006844105,0.00005362174,0.9908434,0.00004468556,0.00004260986,0.0001874309,0.00002539694,0.00004397532,0.001729658,0.00002798189,0.001749744,0.004566992],"study_design_scores_gemma":[0.00001897913,0.0001163668,0.9978268,0.00001128777,0.00002719329,0.0005602825,0.00005131132,0.0001624663,0.0002259822,0.00004273424,0.0009533798,0.000003324728],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906265,0.0003631503,0.0003501881,0.0002321045,0.00002337264,0.00002883965,0.006454861,0.00003276829,0.001888327],"genre_scores_gemma":[0.9927074,0.0001211133,0.0005313171,0.00005947108,0.00003725259,0.0000335772,0.005274406,0.00001666579,0.001218625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01180538,"threshold_uncertainty_score":0.03949296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08045071176639222,"score_gpt":0.4749801635350249,"score_spread":0.3945294517686327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}