{"id":"W4417201737","doi":"10.1371/journal.pone.0323230","title":"A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus","year":2025,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Entorhinal cortex; Dentate gyrus; Neurogenesis; Hippocampus; Dendritic spine; Neurodegeneration; Neuroplasticity; Long-term potentiation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004494812,0.001927864,0.0009757846,0.002060233,0.0008945798,0.0006839298,0.001091699,0.002121263,0.006627594],"category_scores_gemma":[0.0002325351,0.0008568522,0.0009728451,0.0006944037,0.001012895,0.0008394695,0.0006495047,0.002977087,0.002530741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008996941,"about_ca_system_score_gemma":0.0006914703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365265,"about_ca_topic_score_gemma":0.003131281,"domain_scores_codex":[0.9993056,0.00005921761,0.00008570073,0.0002290198,0.0001637557,0.0001566961],"domain_scores_gemma":[0.9995229,0.00003315901,0.0001429245,0.00007607072,0.00006099818,0.0001638605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009649451,0.001271598,0.000477998,0.0001183417,0.00003705938,0.0006498724,0.0001492469,0.0001461676,0.99139,0.0008752474,0.0006005103,0.00331883],"study_design_scores_gemma":[0.00105815,0.00987185,0.01509241,0.0002068997,0.0002719165,0.004417841,0.0003378901,0.002487516,0.9348193,0.001403947,0.02993982,0.00009247259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712195,0.002066214,0.01009819,0.001108093,0.0004778088,0.000866437,0.005446691,0.001661554,0.007055582],"genre_scores_gemma":[0.9057617,0.003899645,0.01633683,0.0008821678,0.0001451439,0.003415192,0.006855923,0.0004836502,0.06221978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006627594,"threshold_uncertainty_score":0.0221715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07656314536954102,"score_gpt":0.2489020242918162,"score_spread":0.1723388789222752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}