{"id":"W4417201848","doi":"10.1158/1557-3265.earlyonsetca25-pr011","title":"Abstract PR011: Early-onset colorectal cancer is characterized by transcriptional changes indicating increased epithelial-mesenchymal transition and metastatic potential","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Colorectal cancer; Microsatellite instability; Cancer; Incidence (geometry); Rectum; Metastasis; Gene; Primary tumor; Overall survival; Survival rate","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773889,0.0003064373,0.0004940058,0.0004184389,0.0004871742,0.0006832099,0.0003239577,0.0003258528,0.007681757],"category_scores_gemma":[0.000701397,0.0002102564,0.0004693676,0.001033278,0.0003486355,0.0004785679,0.0006711847,0.0004268509,0.002865078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004493487,"about_ca_system_score_gemma":0.0005505137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004461779,"about_ca_topic_score_gemma":0.008172493,"domain_scores_codex":[0.9996901,0.00001732515,0.00001724393,0.0001715125,0.00006981396,0.00003407039],"domain_scores_gemma":[0.999543,0.00009633727,0.000138399,0.00004155499,0.0001174095,0.00006331874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00183192,0.00005896448,0.131266,0.003008381,0.0003614231,0.0006679031,0.0004203599,0.002120353,0.7677668,0.002054804,0.03332632,0.05711673],"study_design_scores_gemma":[0.000115946,0.0006200874,0.7011066,0.0002330431,0.0005087228,0.003144001,0.0005505576,0.006003339,0.1250621,0.002764556,0.1597871,0.0001038835],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6603629,0.008603945,0.02568959,0.0007048432,0.0004566008,0.0001207959,0.2830938,0.002988332,0.01797918],"genre_scores_gemma":[0.7034472,0.003556358,0.01716529,0.001011154,0.0001372456,0.0002123248,0.2571716,0.001183998,0.0161148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007681757,"threshold_uncertainty_score":0.02569807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09945902048054259,"score_gpt":0.4581596973008317,"score_spread":0.3587006768202891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}