{"id":"W4417202810","doi":"10.1158/1557-3265.earlyonsetca25-c013","title":"Abstract C013: Spatial immune profiling of early- and late-onset colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immune system; Colorectal cancer; Cytotoxic T cell; T cell; Biomarker; Immunotherapy; Cell; Intestinal mucosa","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094406,0.0001149471,0.0002678462,0.00006179013,0.0001080774,0.00002818179,0.0002417919,0.0002708281,0.0000663557],"category_scores_gemma":[0.0002936032,0.0001043659,0.0001142763,0.0001650901,0.0005426464,0.000003921104,0.0001701193,0.0004783834,0.000002349429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002471208,"about_ca_system_score_gemma":0.0005778297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004726463,"about_ca_topic_score_gemma":0.001312893,"domain_scores_codex":[0.9984167,0.0001536867,0.0004754298,0.000409406,0.0002149889,0.0003297976],"domain_scores_gemma":[0.9991459,0.0001701023,0.00006819405,0.0002252161,0.0002936496,0.00009691733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001461124,0.0001300898,0.4067252,0.0001177952,0.0001060288,0.000002498095,0.00002678136,0.00001510599,0.5690103,0.00001781474,0.0002531708,0.02213411],"study_design_scores_gemma":[0.001035023,0.0003966012,0.5382909,0.0001069114,0.0000168849,3.368053e-7,0.00002020199,0.00009756988,0.4580536,0.0001034016,0.001763032,0.0001155163],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994217,0.003928307,0.00005394025,0.0003074392,0.0004309241,0.000306275,0.00007898793,0.00000730104,0.0006698227],"genre_scores_gemma":[0.9950505,0.003962908,0.00008963921,0.00006685855,0.0002551982,0.00007308306,0.00002578111,0.00001625005,0.0004597264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1315657,"threshold_uncertainty_score":0.7145029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08931991019248108,"score_gpt":0.451829288922755,"score_spread":0.3625093787302739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}