{"id":"W4417202891","doi":"10.1158/1557-3265.earlyonsetca25-c037","title":"Abstract C037: Fructose-induced Akkermansia muciniphila promotes colorectal cancer progression through N-acetylneuraminic acid-mediated macrophage reprogramming","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Akkermansia muciniphila; Immune system; Macrophage polarization; Tumor progression; Mucin; Colorectal cancer; Macrophage; Tumor microenvironment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650932,0.0003325063,0.000263505,0.0003408484,0.0002721157,0.0003700751,0.0001334212,0.0003859004,0.003158265],"category_scores_gemma":[0.0001541095,0.000101558,0.0003894449,0.0003010672,0.0001966985,0.0002180965,0.0002984383,0.0005627732,0.0007559594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780071,"about_ca_system_score_gemma":0.000349345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109926,"about_ca_topic_score_gemma":0.001295228,"domain_scores_codex":[0.9998153,0.00002132411,0.0000115946,0.00005135889,0.00005238774,0.00004805925],"domain_scores_gemma":[0.9998791,0.000009730429,0.00003499744,0.0000101959,0.00003150766,0.00003446366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003812411,0.00002569126,0.0008079941,0.0001401309,0.0000129679,0.00009712189,0.00002057558,0.00005278855,0.9952689,0.00007211941,0.0002756156,0.002844865],"study_design_scores_gemma":[0.00006266501,0.0009586429,0.05202286,0.00009549625,0.00008191396,0.0008770026,0.0002944051,0.001753351,0.9236135,0.000291835,0.01991497,0.0000333406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810274,0.004170642,0.004566085,0.0004983795,0.0001948625,0.00008795464,0.006228612,0.0002927471,0.002933447],"genre_scores_gemma":[0.9841965,0.001911675,0.003127908,0.0003883032,0.00004192335,0.000111696,0.004641855,0.00007141529,0.005508771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003158265,"threshold_uncertainty_score":0.01056546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1772420420816746,"score_gpt":0.5575806879932992,"score_spread":0.3803386459116246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}