{"id":"W4417206891","doi":"10.1016/j.rpth.2025.103021","title":"HTRS2025.P1.1 Safety and efficacy of Mim8 prophylaxis in patients with hemophilia A with or without inhibitors: Results from the phase 3, open-label, randomized controlled FRONTIER2 study","year":2025,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medicinski Fakultet, Sveučilište u Zagrebu; National Health Laboratory Service; McMaster University; Novo Nordisk; Sveučilište u Zagrebu","keywords":"Randomized controlled trial; Phase (matter); Clinical trial; Adverse effect; MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001712113,0.001139236,0.001936771,0.0003068852,0.0002792352,0.0008133306,0.000671242,0.001162533,0.005427767],"category_scores_gemma":[0.001329478,0.0003532749,0.001958647,0.0003640446,0.0007563042,0.0007040094,0.0002535034,0.002348469,0.0007394816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004655047,"about_ca_system_score_gemma":0.0006722164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000695085,"about_ca_topic_score_gemma":0.001339796,"domain_scores_codex":[0.9992688,0.0004662637,0.00003356855,0.00008653245,0.000063254,0.00008148066],"domain_scores_gemma":[0.9992602,0.0002679647,0.0002479427,0.00005034428,0.00003065088,0.0001428825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9616442,0.004572941,0.001156024,0.0007257624,0.001847598,0.00005416025,0.00004131627,0.0003159431,0.003466914,0.0001864375,0.001344332,0.02464432],"study_design_scores_gemma":[0.9221119,0.07018938,0.004853197,0.00003824174,0.0009899568,0.00005201601,0.00002107881,0.0003891534,0.0005099726,0.0001627376,0.0006654062,0.00001702076],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838756,0.007782078,0.001047297,0.0008960736,0.0003011845,0.001335043,0.002254158,0.0001491825,0.002359502],"genre_scores_gemma":[0.9889475,0.003121262,0.001603296,0.000933358,0.0003882675,0.001203271,0.001913206,0.00002391512,0.001865985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005427767,"threshold_uncertainty_score":0.01815772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09984595679332926,"score_gpt":0.4481153148596547,"score_spread":0.3482693580663254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}