{"id":"W4417206910","doi":"10.1016/j.rpth.2025.103155","title":"HTRS2025.O8C.3 Alfa-PROTECT: A Phase 3, Open-Label Study to Evaluate the Safety of Damoctocog Alfa Pegol in Previously Treated Children Aged 7 to <12 Years With Severe Hemophilia A","year":2025,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"","keywords":"Clinical trial; Phase (matter); Incidence (geometry); Phases of clinical research; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020572,0.0008898803,0.001215161,0.0002058662,0.000314945,0.0007192701,0.0004781867,0.000876955,0.004094646],"category_scores_gemma":[0.000525551,0.0003090391,0.001066744,0.0001994446,0.0007072793,0.0006419417,0.0002331396,0.002445427,0.0009339445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007130247,"about_ca_system_score_gemma":0.001049497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216011,"about_ca_topic_score_gemma":0.002777177,"domain_scores_codex":[0.999663,0.0001531876,0.0000138311,0.00004981542,0.00004328963,0.00007690937],"domain_scores_gemma":[0.9996013,0.00007158189,0.00009678556,0.00002986725,0.0000191917,0.0001813157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8125665,0.03961033,0.008329369,0.00079422,0.001827857,0.0005914072,0.0003210959,0.001237911,0.03480187,0.000699927,0.005497171,0.09372249],"study_design_scores_gemma":[0.6027561,0.3689727,0.01454159,0.00006419855,0.0006355729,0.0007735718,0.0001082838,0.001207626,0.004901751,0.0002135813,0.00579023,0.00003465736],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918024,0.002350676,0.0007523286,0.0004037879,0.00012886,0.001302259,0.001276296,0.000133929,0.001849489],"genre_scores_gemma":[0.9904212,0.001743905,0.001575464,0.0007670457,0.0001493788,0.001337302,0.001699903,0.00004022719,0.002265555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004094646,"threshold_uncertainty_score":0.01369798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1742177534566362,"score_gpt":0.49538479039801,"score_spread":0.3211670369413738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}