{"id":"W4417207019","doi":"10.1016/j.rpth.2025.103156","title":"HTRS2025.O8C.4 Efficacy and Safety of Giroctocogene Fitelparvovec in Adults With Moderately Severe to Severe Hemophilia A: Results From the Phase 3 AFFINE Gene Therapy Trial","year":2025,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Barts Health NHS Trust; Universität Wien; Imperial College Healthcare NHS Trust; Imperial College London; University of Washington; University Hospital Southampton NHS Foundation Trust; Medizinische Universität Wien; University of Pittsburgh","keywords":"Clinical trial; Phase (matter); Genetic enhancement; Phases of clinical research; Incidence (geometry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008919219,0.0004809457,0.0006182843,0.0001057649,0.0001637219,0.0006285578,0.0002585785,0.0006229532,0.003591425],"category_scores_gemma":[0.0004483756,0.0001404041,0.0007876911,0.0001445038,0.0003441909,0.0002937255,0.0001396104,0.001444767,0.0006611679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448485,"about_ca_system_score_gemma":0.0004951681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007980163,"about_ca_topic_score_gemma":0.00173152,"domain_scores_codex":[0.9997656,0.0001195184,0.000009983852,0.00002932809,0.00003001222,0.00004549229],"domain_scores_gemma":[0.9997264,0.000054976,0.00009767537,0.00001717312,0.00001352487,0.00009033522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7544228,0.01265217,0.02275881,0.001433439,0.00273812,0.0004245107,0.000242288,0.002355387,0.02286748,0.001074146,0.01755356,0.1614772],"study_design_scores_gemma":[0.7187184,0.2017267,0.05758441,0.000201706,0.001617138,0.0009876116,0.00009556567,0.003043297,0.005142943,0.0007448097,0.01009078,0.00004653311],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867748,0.005280451,0.0003486479,0.0008865688,0.0001102558,0.0005511874,0.002484488,0.0001129816,0.003450675],"genre_scores_gemma":[0.9911457,0.002012579,0.0006006447,0.0008940264,0.0001542715,0.0006904291,0.002538281,0.00001881365,0.001945315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003591425,"threshold_uncertainty_score":0.01201451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1471378635530606,"score_gpt":0.4493939460076065,"score_spread":0.3022560824545459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}