{"id":"W4417209005","doi":"10.1158/1557-3265.earlyonsetca25-c024","title":"Abstract C024: Somatic mutations in early-onset colorectal cancer: insights from a U.S. Hispanic cohort","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Somatic cell; Colorectal cancer; Germline mutation; Lynch syndrome; Exome sequencing; Exome; MLH1","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002849773,0.0002399613,0.0001530931,0.0005647848,0.0005559662,0.0004373213,0.0002575633,0.0001935742,0.002713671],"category_scores_gemma":[0.0005476766,0.0001396523,0.0002078064,0.0008025607,0.000148539,0.000151178,0.0005176634,0.0002730055,0.0003756375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809261,"about_ca_system_score_gemma":0.0002630155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01808933,"about_ca_topic_score_gemma":0.01535962,"domain_scores_codex":[0.9998949,0.00001880137,0.000006496354,0.00004159953,0.00001728977,0.0000208376],"domain_scores_gemma":[0.9997689,0.00002147989,0.00006195953,0.00003662427,0.00004779727,0.00006318947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001805759,0.0000459515,0.9928339,0.00001696929,0.00007293178,0.0004408501,0.0003397647,0.00003810044,0.002083962,0.00004235125,0.0009559373,0.002948678],"study_design_scores_gemma":[0.00001214805,0.00005219743,0.9968333,0.00001046187,0.00004238589,0.0007093744,0.0007464041,0.0001318992,0.0002081055,0.00003786132,0.001211154,0.000004777266],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972829,0.00008963837,0.00009304575,0.00005043645,0.00000358126,0.00001181461,0.001927109,0.000004930826,0.0005366145],"genre_scores_gemma":[0.9968858,0.0001573856,0.0001653217,0.00007372907,0.00001205605,0.00001942355,0.002186182,0.00001082953,0.0004893387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01808933,"threshold_uncertainty_score":0.03596807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0552683793899181,"score_gpt":0.4404204596819934,"score_spread":0.3851520802920753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}