{"id":"W4417209333","doi":"10.1158/1557-3265.earlyonsetca25-c017","title":"Abstract C017: Exogenous carcinogenic exposures in early-onset pancreatic carcinogenesis: Insights from alcohol and tobacco-driven models","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Carcinogenesis; Pancreas; Carcinogen; Pancreatitis; Immune system; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Metaplasia; Stromal cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005784106,0.000665052,0.0005117945,0.0007308456,0.0004529918,0.001088877,0.0006047148,0.0009096204,0.005045922],"category_scores_gemma":[0.0002574449,0.0002603169,0.000815275,0.0004572523,0.000621053,0.0006557363,0.0009281288,0.002158036,0.001244439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007818826,"about_ca_system_score_gemma":0.0008981135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001528402,"about_ca_topic_score_gemma":0.002365808,"domain_scores_codex":[0.9996122,0.00004700173,0.00002586028,0.0001039674,0.0001439809,0.0000671292],"domain_scores_gemma":[0.9995554,0.00004210354,0.0001060564,0.00007259758,0.00007668564,0.0001470531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00120642,0.0004005459,0.006476958,0.0007709174,0.00008354407,0.0005925006,0.0001362413,0.0006654399,0.9648585,0.004350396,0.002576936,0.0178817],"study_design_scores_gemma":[0.000171943,0.002498105,0.05018695,0.0004705381,0.0003600617,0.002752051,0.0005207977,0.008569537,0.83598,0.006105931,0.09228075,0.0001033481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8705575,0.02073953,0.0551565,0.005468375,0.0009084831,0.0004868284,0.0152844,0.001359523,0.03003881],"genre_scores_gemma":[0.9230252,0.02068463,0.01395317,0.001410521,0.0002305501,0.0005188994,0.01044313,0.0003519242,0.02938198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005045922,"threshold_uncertainty_score":0.01688027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1380299526074797,"score_gpt":0.4090477430528915,"score_spread":0.2710177904454118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}