{"id":"W4417209333","doi":"10.1158/1557-3265.earlyonsetca25-c017","title":"Abstract C017: Exogenous carcinogenic exposures in early-onset pancreatic carcinogenesis: Insights from alcohol and tobacco-driven models","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Carcinogenesis; Pancreas; Carcinogen; Pancreatitis; Immune system; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Metaplasia; Stromal cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005992727,0.0002202241,0.0004274459,0.0001544612,0.0001637984,0.00007557217,0.0004536031,0.0004268588,0.00001996146],"category_scores_gemma":[0.0001678924,0.000203952,0.0001564553,0.0002706071,0.0003696599,0.00001204692,0.0002362867,0.0005587544,0.000007100452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007607572,"about_ca_system_score_gemma":0.0005679816,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01184867,"about_ca_topic_score_gemma":0.01008122,"domain_scores_codex":[0.997272,0.0004070579,0.000637514,0.0008392435,0.0003243642,0.0005197972],"domain_scores_gemma":[0.9985994,0.0003206263,0.00005942132,0.0006094474,0.0002075348,0.0002035313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008914277,0.0002288981,0.8736555,0.00005959472,0.0001683107,0.00003441047,0.0002720053,0.0002004893,0.1184036,0.00003238258,0.0003741336,0.005679278],"study_design_scores_gemma":[0.002315819,0.0003447777,0.9505123,0.0001854372,0.00004915718,0.000001226821,0.0001631496,0.0003642455,0.04339418,0.001531834,0.000840051,0.0002978501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801105,0.01828826,0.00004489654,0.0001454834,0.0002358241,0.0004691993,0.00008794121,0.00001337287,0.0006044843],"genre_scores_gemma":[0.9922878,0.006611681,0.00009992877,0.0002592528,0.0002946379,0.0001532506,0.00007596654,0.00003171849,0.0001857616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07685678,"threshold_uncertainty_score":0.9947315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1380299526074797,"score_gpt":0.4090477430528915,"score_spread":0.2710177904454118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}