{"id":"W4417210744","doi":"10.1158/1557-3265.earlyonsetca25-c031","title":"Abstract C031: Evexomostat (SDX-7320), a methionine aminopeptidase type 2 (METAP2) inhibitor, inhibits obesity-accelerated tumor growth and stimulates weight loss in obese mice","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Weight loss; Ovariectomized rat; Obesity; Adipose tissue; Diet-induced obese; Methionine; Mammary tumor; Weight gain; White adipose tissue","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182217,0.000691032,0.0004063079,0.0004261,0.0001591079,0.0001755439,0.0002787441,0.0003618156,0.003488902],"category_scores_gemma":[0.00006941915,0.0001221937,0.0002968928,0.0003130181,0.000234335,0.0001811087,0.0001103256,0.00100817,0.0006366173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436651,"about_ca_system_score_gemma":0.0004729755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392817,"about_ca_topic_score_gemma":0.001928302,"domain_scores_codex":[0.9998899,0.00001039203,0.000008935399,0.00001940687,0.00003389912,0.00003752992],"domain_scores_gemma":[0.9999202,0.00000760933,0.00001902018,0.000006988037,0.00001007604,0.00003588938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003666389,0.0004988248,0.0002972922,0.0001099741,0.00001814112,0.00009180981,0.000006004242,0.0001121412,0.9872854,0.0001287036,0.0005650063,0.00722022],"study_design_scores_gemma":[0.000668032,0.004775569,0.005814478,0.00001075475,0.00004456164,0.0004507834,0.00001810633,0.0006474063,0.9832724,0.00004502435,0.004243881,0.000008916425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881671,0.003046174,0.001873942,0.0002964344,0.0001154205,0.0001280006,0.002774696,0.0003086042,0.003289471],"genre_scores_gemma":[0.9850781,0.002196763,0.002405938,0.000181711,0.00003691993,0.0001355172,0.003435076,0.00004771528,0.006482226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003488902,"threshold_uncertainty_score":0.01167154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1207082915983635,"score_gpt":0.4798057568236778,"score_spread":0.3590974652253143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}