{"id":"W4417210855","doi":"10.1158/1557-3265.earlyonsetca25-pr012","title":"Abstract PR012: Transcriptomic and pathway analyses patterns in early-onset and late-onset microsatellite stable colorectal cancer: Results from the ORIEN Network","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Microsatellite instability; Colorectal cancer; Transcriptome; Microsatellite; Cancer; Germline; Exome; Genomics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001194365,0.0004068902,0.0003362553,0.0009789747,0.0004517671,0.0007125081,0.0005415667,0.0003657865,0.00231375],"category_scores_gemma":[0.001653661,0.0001327817,0.0006305595,0.001075423,0.0002012247,0.0002829212,0.001246022,0.0003858355,0.0007875845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004568427,"about_ca_system_score_gemma":0.0006364083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005841772,"about_ca_topic_score_gemma":0.012649,"domain_scores_codex":[0.9993343,0.0001340905,0.00003585498,0.0002928457,0.0001167404,0.00008619137],"domain_scores_gemma":[0.9993519,0.0001571987,0.0001183797,0.00009244,0.000170759,0.0001093069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004441575,0.0003153628,0.8334612,0.0009606018,0.001246118,0.0006509329,0.000582038,0.003429481,0.07210942,0.0005050222,0.02321093,0.05908734],"study_design_scores_gemma":[0.00009679728,0.0004344509,0.9722539,0.00008404186,0.0004732793,0.0008344034,0.0004982168,0.003730114,0.004821187,0.0003767594,0.01636461,0.0000322695],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8954551,0.001394644,0.002217743,0.0004419369,0.00005000764,0.0001204992,0.09628503,0.0002778354,0.003757284],"genre_scores_gemma":[0.7794394,0.0007967518,0.00733214,0.0004522576,0.00005065788,0.000249973,0.208859,0.0001412508,0.002678544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005841772,"threshold_uncertainty_score":0.01161551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0922474449862485,"score_gpt":0.4380795870415172,"score_spread":0.3458321420552687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}