{"id":"W4417223543","doi":"10.1016/j.isci.2025.114405","title":"A stiffness-gated YAP-β-catenin axis orchestrates AXIN2 expression in metastatic breast cancer","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Waterloo; McMaster University","funders":"Mitacs; Genome Canada","keywords":"Extracellular matrix; Breast cancer; Wnt signaling pathway; Matrigel; AXIN2; Cytoskeleton; Mechanotransduction; Cancer cell; Metastasis; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352096,0.00009990823,0.00009379363,0.00008138995,0.00007972025,0.0000424776,0.0002175619,0.00004597379,0.0001021821],"category_scores_gemma":[0.00004390674,0.00008531129,0.00003918529,0.0003498039,0.00005931067,0.00001072985,0.0001044664,0.00008394847,0.000006579922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002393771,"about_ca_system_score_gemma":0.0001637713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002802912,"about_ca_topic_score_gemma":0.0002691518,"domain_scores_codex":[0.9991904,0.0000359385,0.0001557002,0.0003270768,0.0000909411,0.0001999692],"domain_scores_gemma":[0.9996399,0.00001084502,0.00004418569,0.0001929116,0.00006793327,0.00004425431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002341373,0.00006235011,0.0004031656,0.000009007478,0.000005898958,0.000002898373,0.00003301739,0.0001239566,0.9928955,0.0001634088,0.0004621788,0.005815194],"study_design_scores_gemma":[0.0003451538,0.00003289807,0.01281746,0.0001101996,0.00001050862,0.0000137132,0.000197144,0.00389605,0.97332,0.0003537131,0.008738731,0.0001644349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928563,0.0009873969,0.004261927,0.000589118,0.0002945123,0.0001366544,0.00003522476,0.00001073144,0.0008281245],"genre_scores_gemma":[0.9976858,0.0001566585,0.0002878107,0.0001532429,0.00001663282,0.00003567265,0.00001806072,0.000005704576,0.00164034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01957552,"threshold_uncertainty_score":0.3478893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428718049967177,"score_gpt":0.2953437011683807,"score_spread":0.2810565206687089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}