{"id":"W4417228722","doi":"10.3390/jpm15120619","title":"Gene Therapy for Inherited Retinal Disease: Current Strategies, Personalized Medicine, and Future Implications—A Comprehensive Review","year":2025,"lang":"en","type":"article","venue":"Journal of Personalized Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Canada; University of Toronto; University of British Columbia; Western University","funders":"","keywords":"Genetic enhancement; Retinal; Genome editing; Gene delivery; Gene; Retinal pigment epithelium; Viral vector; Clinical trial; Gene transfer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004557283,0.0002449651,0.0005377349,0.0001298561,0.0001192867,0.00001287328,0.0002040125,0.00007735133,0.0001196342],"category_scores_gemma":[0.0002254679,0.0001655804,0.0001560389,0.0002320462,0.0003840198,0.00001111849,0.00002791753,0.0001651465,2.952287e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002481377,"about_ca_system_score_gemma":0.0004638603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003416581,"about_ca_topic_score_gemma":8.926196e-7,"domain_scores_codex":[0.9985457,0.0001078925,0.0005911633,0.0002722703,0.0002791786,0.0002037729],"domain_scores_gemma":[0.9983642,0.00006707901,0.0003911425,0.0001808243,0.0007933346,0.0002034155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008574552,0.0002842167,0.005360242,0.004869356,0.0009623897,0.00001923601,0.0009691755,0.000001149969,0.1713538,0.006875165,0.6742486,0.1264821],"study_design_scores_gemma":[0.006488134,0.0005890938,0.01780249,0.001937063,0.0002564923,0.00005391818,0.001102825,0.000004189325,0.0001009256,0.0009851296,0.9705103,0.000169411],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03756611,0.8964767,0.002374358,0.06199657,0.0005143618,0.0006507639,0.00001821694,0.000007238568,0.0003956284],"genre_scores_gemma":[0.01246945,0.9745203,0.00137861,0.008667334,0.00191458,0.00006553584,0.0003762369,0.00002633763,0.0005815679],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2962617,"threshold_uncertainty_score":0.6752174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099703777911923,"score_gpt":0.3582245573776093,"score_spread":0.3272275195984901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}