{"id":"W4417228722","doi":"10.3390/jpm15120619","title":"Gene Therapy for Inherited Retinal Disease: Current Strategies, Personalized Medicine, and Future Implications—A Comprehensive Review","year":2025,"lang":"en","type":"article","venue":"Journal of Personalized Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Canada; University of Toronto; University of British Columbia; Western University","funders":"","keywords":"Genetic enhancement; Retinal; Genome editing; Gene delivery; Gene; Retinal pigment epithelium; Viral vector; Clinical trial; Gene transfer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001108547,0.0006725419,0.001067674,0.001983329,0.0002857663,0.001428671,0.0008658915,0.001311817,0.002135915],"category_scores_gemma":[0.0008685916,0.0002417861,0.0004933322,0.001508959,0.0009070578,0.002094264,0.0006275343,0.002464425,0.0009104502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006986424,"about_ca_system_score_gemma":0.001126438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007833444,"about_ca_topic_score_gemma":0.001416136,"domain_scores_codex":[0.9997589,0.00004817717,0.00003679464,0.00003817589,0.00008999995,0.00002795561],"domain_scores_gemma":[0.9993092,0.0004344805,0.00006139022,0.00001928909,0.0001275754,0.0000481573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008217692,0.0001078306,0.0002049958,0.01310695,0.00007655058,0.0002257454,0.0001135424,0.0004926808,0.002931507,0.007939924,0.03246332,0.9422549],"study_design_scores_gemma":[0.0000175734,0.0001524734,0.0006185747,0.004020466,0.0001043164,0.001508662,0.0001209915,0.0002327573,0.0008907731,0.004682044,0.9876209,0.0000305071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001053399,0.9983584,0.0002450983,0.0006244773,0.0002007032,0.000003741585,0.000006898506,0.000007236968,0.0004481106],"genre_scores_gemma":[0.0004881494,0.9985803,0.0002358932,0.000302822,0.0002044175,0.000005248498,0.0000135269,0.000001608211,0.0001680752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002135915,"threshold_uncertainty_score":0.007145286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099703777911923,"score_gpt":0.3582245573776093,"score_spread":0.3272275195984901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}