{"id":"W4417230925","doi":"10.1186/s12872-025-05413-0","title":"Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1","year":2025,"lang":"en","type":"article","venue":"BMC Cardiovascular Disorders","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Queen's University; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"In vivo; Angiology; Cardiac surgery; Function (biology); Cardiac function curve; Cardioprotection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005935273,0.0006541079,0.0006781304,0.001394675,0.0004627207,0.0009371124,0.0003833921,0.0005482947,0.002483108],"category_scores_gemma":[0.0005982934,0.000165956,0.0009021458,0.001000184,0.0003087758,0.0004293407,0.0005622823,0.0008562522,0.001558288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349346,"about_ca_system_score_gemma":0.0004751193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006840497,"about_ca_topic_score_gemma":0.001042716,"domain_scores_codex":[0.999433,0.0000377474,0.00004065369,0.000236095,0.0001876161,0.00006484519],"domain_scores_gemma":[0.9994689,0.0001186785,0.0001433875,0.00007192136,0.0001235828,0.00007364013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007409786,0.0001369157,0.0117367,0.000554936,0.0001529964,0.0003343883,0.00008089699,0.001348767,0.9644467,0.0002781549,0.00181934,0.01836919],"study_design_scores_gemma":[0.0001296687,0.001287116,0.3070838,0.0002043585,0.0008842294,0.003537707,0.0005562869,0.08125562,0.5616629,0.002836042,0.04041021,0.000152118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8698412,0.003504899,0.06182627,0.0008314876,0.00020179,0.000145632,0.05508573,0.004734741,0.003828235],"genre_scores_gemma":[0.8065931,0.002100992,0.07788065,0.0007570428,0.0001073532,0.0003187453,0.107731,0.0008879295,0.003623222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002483108,"threshold_uncertainty_score":0.008306801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00396825001241401,"score_gpt":0.205380551399198,"score_spread":0.201412301386784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}