{"id":"W4417230978","doi":"10.1172/jci188458","title":"CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Cancer Institute; National Institutes of Health; Seagen; Puma Biotechnology; Susan G. Komen; Cancer Prevention and Research Institute of Texas; Daiichi Sankyo Europe; U.S. Department of Defense; Breast Cancer Research Foundation; Sanofi; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; NightstaRx; University of Texas Southwestern Medical Center; Susan G. Komen for the Cure; Pfizer; Amgen","keywords":"Tumor microenvironment; Stromal cell; CXCL11; Letrozole; Immune system; CXCL10; CXCR3; Chemokine; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008933604,0.0001070718,0.0001686254,0.0001804802,0.00008793303,0.0002448362,0.00005631843,0.0001350443,0.001119895],"category_scores_gemma":[0.000122217,0.00008074696,0.0001216746,0.0001259435,0.00009449126,0.0001142317,0.0001133087,0.0002444401,0.0001973261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001895708,"about_ca_system_score_gemma":0.0001273021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004413974,"about_ca_topic_score_gemma":0.000904333,"domain_scores_codex":[0.9999089,0.00001694768,0.000005927651,0.00002063641,0.00001646001,0.00003112568],"domain_scores_gemma":[0.9999518,0.000008253929,0.00001478069,0.00000325828,0.000008596679,0.0000132545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001200874,0.00009499763,0.03794217,0.0001503494,0.000032148,0.0001871529,0.0001762224,0.0003493773,0.9363176,0.00006822764,0.0003278581,0.02315295],"study_design_scores_gemma":[0.0001117969,0.001885214,0.6621313,0.00005079646,0.000181813,0.001360789,0.001156729,0.002283024,0.316575,0.0002637283,0.01397496,0.00002479636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969006,0.002020197,0.0002326717,0.00007199521,0.000009380703,0.00001134303,0.000186613,0.00001535644,0.0005519371],"genre_scores_gemma":[0.9976797,0.0007136036,0.0002683258,0.00008492143,0.00001016715,0.00002085828,0.0002727198,0.000004681533,0.0009451133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119895,"threshold_uncertainty_score":0.00374639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0442191220273328,"score_gpt":0.3736691601185129,"score_spread":0.3294500380911801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}