{"id":"W4417239795","doi":"10.2218/gtopdb/f119/2025.4","title":"Aquaporins in GtoPdb v.2025.4","year":2025,"lang":"","type":"article","venue":"IUPHAR/BPS Guide to Pharmacology CITE","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Aquaporin; Intracellular; Endoplasmic reticulum; Lipid-anchored protein; Secretion; Gene isoform; Function (biology); Vacuole; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007240056,0.0006721715,0.000687399,0.0007265601,0.000209016,0.00005438107,0.0007429747,0.0008589928,0.001435168],"category_scores_gemma":[0.00004746257,0.0007949777,0.0003381512,0.00105939,0.0002285391,0.00002227637,0.0002866818,0.0005360306,0.0002930056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212367,"about_ca_system_score_gemma":0.0007230455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009884311,"about_ca_topic_score_gemma":0.0002192643,"domain_scores_codex":[0.9955791,0.0002694787,0.001346564,0.001371327,0.000263797,0.001169708],"domain_scores_gemma":[0.9985468,0.00005076432,0.0002157135,0.0005697745,0.0002606518,0.0003563088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001330652,0.0005886423,0.01289457,0.0002138289,0.0004984391,0.0001657355,0.000332129,0.002467943,0.7390923,0.0004225442,0.2281347,0.01385847],"study_design_scores_gemma":[0.003628051,0.0002323462,0.007544379,0.00008243947,0.000225948,0.000008018965,0.00009043199,0.0003488748,0.2953268,0.00008495299,0.6918502,0.0005775227],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265333,0.007698197,0.005540332,0.01167879,0.009778567,0.002136961,0.0002603761,0.00007920322,0.03629422],"genre_scores_gemma":[0.9403025,0.001799671,0.0002514972,0.01037236,0.00103454,0.0002269107,0.0004601592,0.00004972408,0.04550264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4637155,"threshold_uncertainty_score":0.9994777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00807952158917878,"score_gpt":0.33972023824709,"score_spread":0.3316407166579112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}