{"id":"W4417245919","doi":"10.1016/j.cell.2025.11.021","title":"Are ultrasensitive ctDNA assays ready for clinical use in early-stage NSCLC?","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Lung cancer; Disease; Cancer; Circulating tumor DNA; Lung disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008095694,0.0006454755,0.001575094,0.0006625689,0.0003179765,0.003884995,0.000995819,0.003433461,0.005326074],"category_scores_gemma":[0.01928799,0.0008675845,0.0007646821,0.0009394993,0.001463408,0.003397292,0.0004942109,0.00350225,0.00356038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009227366,"about_ca_system_score_gemma":0.002111995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002162978,"about_ca_topic_score_gemma":0.003067035,"domain_scores_codex":[0.9975618,0.0008589801,0.0002614485,0.0003214084,0.0007434094,0.0002529475],"domain_scores_gemma":[0.9837242,0.008510711,0.001699741,0.0007928601,0.004511915,0.000760596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005734805,0.0003363355,0.14031,0.002852301,0.0003563517,0.001008111,0.0004006268,0.001637897,0.09423105,0.008455853,0.05043548,0.6942412],"study_design_scores_gemma":[0.0008282344,0.007804878,0.154055,0.003532893,0.001694079,0.007074931,0.002928718,0.008726996,0.1839391,0.04723625,0.5816645,0.0005144962],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1380992,0.5526772,0.1097787,0.1551982,0.01623773,0.0005547328,0.005152865,0.001923583,0.0203778],"genre_scores_gemma":[0.5877997,0.1916829,0.1234762,0.06218433,0.01505878,0.0009977899,0.004374104,0.0004514059,0.01397483],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008095694,"threshold_uncertainty_score":0.04281467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04335284838572596,"score_gpt":0.3304965851908087,"score_spread":0.2871437368050827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}