{"id":"W4417247341","doi":"10.1159/000549691","title":"Beyond the Scale: How Metabolic Context Reveals Hidden Genetic Risks","year":2025,"lang":"en","type":"letter","venue":"Lifestyle Genomics","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Obesity; Context (archaeology); Body mass index; Cohort; Phenotype; Genetic variants; Abdominal obesity; Gene; Genetic variation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005257173,0.0009647181,0.001835903,0.000677557,0.004464911,0.003800387,0.001730193,0.05247762,0.005010284],"category_scores_gemma":[0.02802881,0.0007423678,0.0009836686,0.0005210899,0.005005197,0.006298814,0.00202072,0.0548854,0.003272087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002939697,"about_ca_system_score_gemma":0.002809309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004742606,"about_ca_topic_score_gemma":0.007104466,"domain_scores_codex":[0.997003,0.001481786,0.0002298632,0.0004361184,0.0005607676,0.0002884348],"domain_scores_gemma":[0.9865273,0.01056295,0.0003417759,0.0004114828,0.0008316764,0.001324905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001678008,0.00008922123,0.002015686,0.00008684404,0.00006422547,0.006181186,0.0007715673,0.000107073,0.0004304201,0.01390562,0.9547883,0.02139203],"study_design_scores_gemma":[0.0003833249,0.0001890037,0.003370569,0.0007189824,0.0001338333,0.009808336,0.002717379,0.00192445,0.0006170649,0.1626873,0.8172192,0.0002306054],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004401717,0.001227523,0.0001471484,0.9884593,0.00857482,0.000005030021,0.00002508591,0.00001576948,0.001105195],"genre_scores_gemma":[0.007861814,0.001286126,0.0003550821,0.9347295,0.05261071,0.00002909252,0.00001494576,0.00002517283,0.0030876],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05247762,"threshold_uncertainty_score":0.02780294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373946736017903,"score_gpt":0.2726413306993705,"score_spread":0.2489018633391915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}