{"id":"W4417247341","doi":"10.1159/000549691","title":"Beyond the Scale: How Metabolic Context Reveals Hidden Genetic Risks","year":2025,"lang":"en","type":"letter","venue":"Lifestyle Genomics","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Obesity; Context (archaeology); Body mass index; Cohort; Phenotype; Genetic variants; Abdominal obesity; Gene; Genetic variation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003964874,0.0007649412,0.001626935,0.000285909,0.0002661837,0.0001498525,0.0008209268,0.001354141,0.0001918692],"category_scores_gemma":[0.0001994879,0.000564174,0.0004698129,0.0003482983,0.0003012699,0.00006084646,0.0003046397,0.00293404,0.0004536895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052506,"about_ca_system_score_gemma":0.0006739734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002098774,"about_ca_topic_score_gemma":0.00003787027,"domain_scores_codex":[0.9966177,0.0003154288,0.0006793445,0.0008831052,0.0005661866,0.0009382312],"domain_scores_gemma":[0.9967168,0.0003540096,0.0004536997,0.00202533,0.000230907,0.0002192336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002763447,0.00002738774,0.0005538724,0.0002213272,0.0006446342,0.0003856354,0.0004174869,6.129787e-7,0.00043286,0.0001651433,0.9534308,0.04369257],"study_design_scores_gemma":[0.0009772046,0.00006476631,0.007149141,0.0001185943,0.003421613,0.0003244145,0.0001203852,0.00000779382,0.0003596382,0.0008243458,0.986124,0.0005080898],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03223388,0.07419062,0.00013214,0.878338,0.003424838,0.002342195,0.0004660887,0.0001730979,0.008699148],"genre_scores_gemma":[0.004229142,0.006447228,0.002028063,0.7902993,0.02248685,0.0001632316,0.00052995,0.0001853735,0.1736309],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1649317,"threshold_uncertainty_score":0.9999423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373946736017903,"score_gpt":0.2726413306993705,"score_spread":0.2489018633391915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}