{"id":"W4417261617","doi":"10.1038/s41467-025-66780-y","title":"Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; Health and Medical Research Fund; Fonds de Recherche du Québec - Santé; INCLIVA Instituto de Investigación Sanitaria; Harvard University; Centre Hospitalier Universitaire de Nice; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Yale University; Moffitt Cancer Center; Ministry of Health and Welfare; Connaught Fund; National Institutes of Health; U.S. Department of Health and Human Services; Ministry of Science and Technology, Taiwan; World Health Organization","keywords":"Microbiome; Lung cancer; Lung; Human microbiome; Human Microbiome Project; Metagenomics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001022103,0.0001964389,0.0006467106,0.0007115456,0.0005240064,0.0008484962,0.0003198662,0.0004748357,0.001996914],"category_scores_gemma":[0.003647947,0.0002752794,0.0005749903,0.0009272428,0.0003677436,0.0003280187,0.0008824845,0.0004226054,0.0006128241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389678,"about_ca_system_score_gemma":0.0002913981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00311432,"about_ca_topic_score_gemma":0.006526771,"domain_scores_codex":[0.9986269,0.0002335762,0.0001216195,0.0005401682,0.0002982788,0.0001793349],"domain_scores_gemma":[0.9983711,0.0004629538,0.0003750861,0.0003287708,0.0002231965,0.0002389583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006652896,0.0000271212,0.976307,0.0000917654,0.000412913,0.00007827664,0.0001448588,0.0001005685,0.01221735,0.00005176469,0.0006239124,0.009279152],"study_design_scores_gemma":[0.00001302598,0.00009581484,0.9955599,0.0000206044,0.0001425164,0.0002709853,0.0001598233,0.0002661229,0.001261957,0.0001321504,0.002069822,0.000007264271],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946162,0.001470958,0.0005579075,0.0001182291,0.00001595435,0.000009635457,0.002404813,0.00002719575,0.0007790053],"genre_scores_gemma":[0.9962147,0.0003328325,0.0002987419,0.0001261032,0.00001390512,0.00001319517,0.002648817,0.00001857757,0.0003331449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00311432,"threshold_uncertainty_score":0.00668031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02331751420239041,"score_gpt":0.3974245726979645,"score_spread":0.3741070584955741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}