{"id":"W4417274113","doi":"10.1101/2025.09.27.678947","title":"CDK11 activates CDK12 to trigger the elongation of RNA Polymerase II","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Jewish Health","keywords":"RNA polymerase II; Transcription (linguistics); Phosphorylation; Kinase; Polymerase; Transcription factor II D; Elongation; RNA polymerase; Linker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601162,0.000423413,0.0002365741,0.0002466111,0.0002674015,0.0005023628,0.0002012602,0.0002161476,0.006374428],"category_scores_gemma":[0.000173778,0.000173916,0.0001941704,0.0001832023,0.0001938553,0.0002260635,0.000273628,0.0004896283,0.003058799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004872966,"about_ca_system_score_gemma":0.0004031863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015608,"about_ca_topic_score_gemma":0.001549924,"domain_scores_codex":[0.9998842,0.00001364885,0.000006339822,0.00003000442,0.00002467858,0.00004105669],"domain_scores_gemma":[0.9999387,0.000009307514,0.00001152325,0.00001167952,0.000008881834,0.00001975707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007525036,0.00007913654,0.003220732,0.0002538525,0.0000233771,0.0005501801,0.00004835942,0.0005574164,0.9741428,0.003259817,0.002010111,0.01510168],"study_design_scores_gemma":[0.00004330586,0.00005976413,0.005541612,0.00001561039,0.000009794338,0.0003445258,0.00002598008,0.001895821,0.9704982,0.000412644,0.0211468,0.000005864171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9172994,0.007674405,0.0218088,0.0009127594,0.0003651245,0.0001496501,0.002142726,0.0009161069,0.04873106],"genre_scores_gemma":[0.966664,0.001939707,0.00585307,0.0001021569,0.00004026158,0.00004827439,0.0009039539,0.00008282693,0.02436575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006374428,"threshold_uncertainty_score":0.02132457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158542580159682,"score_gpt":0.2374682823868899,"score_spread":0.2258828565852931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}