{"id":"W4417274379","doi":"10.1200/jco-25-00924","title":"Venetoclax-Dexamethasone Versus Pomalidomide-Dexamethasone in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma: Primary Results of the Randomized, Phase III CANOVA Study","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Primary (astronomy); Clinical endpoint; Phase (matter); Phases of clinical research; Point (geometry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003434205,0.001405287,0.002468267,0.0004491071,0.000394169,0.001384303,0.0009467608,0.00116613,0.008917699],"category_scores_gemma":[0.002587963,0.0004316813,0.002657586,0.0007073521,0.001172714,0.0006308414,0.0004978478,0.002629432,0.001045672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009902172,"about_ca_system_score_gemma":0.002099598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262898,"about_ca_topic_score_gemma":0.004957155,"domain_scores_codex":[0.9988582,0.0007499148,0.00005050682,0.0001335869,0.00008551846,0.0001222632],"domain_scores_gemma":[0.9983962,0.0004897024,0.0004061862,0.0001223165,0.00008320554,0.0005023424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9677075,0.006976881,0.000797774,0.0008399733,0.001297495,0.00002483581,0.00003874173,0.0005006144,0.001663682,0.0002306161,0.001311513,0.01861049],"study_design_scores_gemma":[0.9161447,0.07707354,0.002452642,0.0001445573,0.001028888,0.00004194015,0.00002786993,0.000339557,0.0005219639,0.0002113332,0.001996775,0.00001616363],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584278,0.02134071,0.0008614595,0.001077694,0.001241203,0.006399205,0.002708773,0.0001608204,0.007782249],"genre_scores_gemma":[0.979618,0.006323597,0.001625928,0.00139986,0.0007010336,0.00388113,0.001990249,0.00004345639,0.004416711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008917699,"threshold_uncertainty_score":0.02983266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09756831229007881,"score_gpt":0.4690346421725317,"score_spread":0.3714663298824529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}