{"id":"W4417274968","doi":"10.1177/08977151251400737","title":"Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared with Orthopedic Injury","year":2025,"lang":"en","type":"article","venue":"Journal of Neurotrauma","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Traumatic brain injury; Biomarker; dNaM; Glasgow Coma Scale; Epigenetics; DNA methylation; Cohort; Injury Severity Score; Concussion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201858,0.0002495624,0.0003658717,0.0002069624,0.00007851578,0.00003366671,0.0003244172,0.0001678871,0.00005147863],"category_scores_gemma":[0.0001256781,0.0001797092,0.0003053553,0.0004446445,0.0001170672,0.00001996853,0.00009039725,0.0003100995,7.102821e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000356523,"about_ca_system_score_gemma":0.0002601591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004440581,"about_ca_topic_score_gemma":0.00001238449,"domain_scores_codex":[0.998033,0.0003143213,0.0007621429,0.0002720078,0.0004027858,0.0002157145],"domain_scores_gemma":[0.9983765,0.00005498661,0.000776455,0.0004299711,0.0002800633,0.00008200169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001645857,0.0001220781,0.007982779,0.00009947451,0.000158944,0.000005024827,0.0001447835,0.0004247472,0.9856616,0.000001920603,0.001061293,0.002691448],"study_design_scores_gemma":[0.001704335,0.0009427473,0.5997185,0.00007900838,0.0002301102,0.00004017034,0.00001362512,0.0002993013,0.3961638,0.00003596956,0.0005771114,0.0001953743],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960457,0.0003345255,0.001035508,0.001549396,0.0005640907,0.0004040053,0.00004583147,0.000006691329,0.00001421821],"genre_scores_gemma":[0.99851,0.0001037121,0.00009159328,0.0007302331,0.0003636211,0.0000112552,0.000009460457,0.00003388513,0.0001462246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5917357,"threshold_uncertainty_score":0.7328328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03006501337341007,"score_gpt":0.2824347273612026,"score_spread":0.2523697139877926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}