{"id":"W4417276764","doi":"10.3390/ijms262411988","title":"Canagliflozin Promotes Structural and Functional Changes in Proximal Tubular Cell Mitochondria of Hypertensive–Diabetic Mice","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"Kidney Foundation of Canada; University of Ottawa","keywords":"Mitochondrion; Canagliflozin; Kidney; MFN2; Diabetes mellitus; In vivo; Oxidative phosphorylation; Inner mitochondrial membrane; Renal function","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850512,0.0003139898,0.0003302733,0.0005138473,0.0001729025,0.0002744688,0.0002060929,0.0003905525,0.001737506],"category_scores_gemma":[0.00009859663,0.0001908996,0.0003433885,0.0002071723,0.0002099281,0.0002338066,0.0001752377,0.0009249697,0.0002534636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567689,"about_ca_system_score_gemma":0.0002316924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098613,"about_ca_topic_score_gemma":0.001376677,"domain_scores_codex":[0.9998323,0.00001857915,0.0000178364,0.00003812117,0.00003951474,0.00005357986],"domain_scores_gemma":[0.9998374,0.000008231258,0.0000468658,0.00001166171,0.00001313579,0.000082774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001306585,0.000252864,0.0006589413,0.00006768492,0.00002002234,0.00005987516,0.00003435955,0.0000599407,0.9947968,0.00009609531,0.0001158007,0.002530969],"study_design_scores_gemma":[0.0003800418,0.00363999,0.04354939,0.00002740715,0.000153858,0.000414029,0.0001421884,0.002396495,0.9451398,0.0002283449,0.003906785,0.00002172625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957994,0.0008353794,0.001618929,0.000220827,0.0000556606,0.00002516217,0.0005167082,0.000139046,0.0007888493],"genre_scores_gemma":[0.9929137,0.0009581052,0.001803926,0.0001637662,0.00002420182,0.00007013736,0.0006843064,0.00003643828,0.003345449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737506,"threshold_uncertainty_score":0.005812526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009414913742161623,"score_gpt":0.249213987124035,"score_spread":0.2397990733818734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}