{"id":"W4417277118","doi":"10.1093/bib/bbaf631.022","title":"Uncovering allosteric communication in cancer-related histone mutations","year":2025,"lang":"en","type":"article","venue":"Briefings in Bioinformatics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; Ontario Institute for Cancer Research; Queen's University","funders":"","keywords":"Allosteric regulation; Histone; Nucleosome; Chromatin; Mutation; Histone methylation; Histone H3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471405,0.00009928814,0.0001158075,0.000119556,0.00005029628,0.00002681459,0.0002037814,0.0001181126,0.000004849356],"category_scores_gemma":[0.00004516652,0.0001154382,0.00003104429,0.0002606513,0.00004187889,0.000009329518,0.0001479303,0.0001075178,0.000003281238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001231265,"about_ca_system_score_gemma":0.0001179177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004119939,"about_ca_topic_score_gemma":0.0008384693,"domain_scores_codex":[0.9992456,0.0000171708,0.0004283964,0.0000975033,0.00005459449,0.0001567401],"domain_scores_gemma":[0.9995405,0.00001427206,0.0001156919,0.0002768853,0.0000337258,0.00001893311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003349647,0.002310209,0.1631906,0.003617119,0.0007865815,0.00002841201,0.02951855,0.3707053,0.193165,0.01699064,0.01801665,0.2013359],"study_design_scores_gemma":[0.01166835,0.0003785299,0.2169248,0.002017854,0.0001435706,0.00005973608,0.003955279,0.6139576,0.03619561,0.01445885,0.09778135,0.002458384],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925813,0.0006253946,0.0005682288,0.0005353319,0.00008196684,0.0001801328,0.00001041502,0.00001450471,0.005402735],"genre_scores_gemma":[0.9874578,0.0009115704,0.01033398,0.0007376632,0.000004634237,0.00003579228,0.0001820415,0.000009825302,0.0003266594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2432524,"threshold_uncertainty_score":0.4707432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005975010853433469,"score_gpt":0.26260469598691,"score_spread":0.2566296851334765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}