{"id":"W4417277794","doi":"10.4081/ejh.2025.4485","title":"A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL &lt;i&gt;5xFAD&lt;/i&gt;","year":2025,"lang":"en","type":"article","venue":"European Journal of Histochemistry","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novelis (Canada)","funders":"","keywords":"Inflammasome; Neuroinflammation; Pathogenesis; Drug; Inflammation; Cognitive decline; Asymptomatic; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402656,0.0005480421,0.0005760709,0.0004464379,0.0001712171,0.0002629757,0.0002726943,0.0004586995,0.0007270015],"category_scores_gemma":[0.00006163985,0.0001237251,0.0003557698,0.0001646489,0.0002285176,0.0002347915,0.0001108092,0.0007720289,0.0001949311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029754,"about_ca_system_score_gemma":0.0002359936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000622122,"about_ca_topic_score_gemma":0.001138004,"domain_scores_codex":[0.9999067,0.00001311551,0.0000109915,0.00002284723,0.00001665837,0.00002966149],"domain_scores_gemma":[0.9999523,0.000004638523,0.0000163734,0.000004466443,0.000005384466,0.00001685724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001073348,0.0005109613,0.0001584061,0.0001343529,0.00002223428,0.0001411938,0.00002486656,0.0001471336,0.991437,0.0002025506,0.0001666623,0.005981279],"study_design_scores_gemma":[0.0005045646,0.01267652,0.003713628,0.00003087183,0.0001097365,0.0006402722,0.0000350412,0.001434152,0.9756708,0.00008149957,0.005083955,0.00001903837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908479,0.00373913,0.002707081,0.0001942981,0.0001075107,0.0001130024,0.0005668607,0.0002238438,0.001500291],"genre_scores_gemma":[0.9897931,0.002723871,0.004104986,0.0001218569,0.00003203287,0.000118625,0.0007700488,0.00001928145,0.002316369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007270015,"threshold_uncertainty_score":0.002432048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005787950666005122,"score_gpt":0.2107702127011827,"score_spread":0.2049822620351776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}