{"id":"W4417280346","doi":"10.1182/bloodadvances.2025017393","title":"Impact of age on graft-versus-host disease and overall survival in pediatric hematopoietic cell transplant recipients","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Moonshot; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; National Institutes of Health; MorphoSys; Seagen; Health Resources and Services Administration; Syndax Pharmaceuticals; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Medac; Jazz Pharmaceuticals; BeiGene; HistoGenetics; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences; Moonshot Research and Development Program; Sanofi; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; Alexion Pharmaceuticals; Mallinckrodt Pharmaceuticals; U.S. Department of Health and Human Services; Astellas Pharma US; Gateway for Cancer Research; Amgen; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation","keywords":"Incidence (geometry); Disease; Hematopoietic stem cell transplantation; Transplantation; Overall survival; Young adult; Hematopoietic cell; Graft-versus-host disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265245,0.0002004826,0.000395337,0.0002609662,0.00002852461,0.000009104606,0.00007717984,0.00006122988,0.00002492109],"category_scores_gemma":[0.00003470105,0.0001663441,0.0001140288,0.0003004214,0.00005099208,0.00009105856,0.00000992056,0.0001350178,0.000004533054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003159328,"about_ca_system_score_gemma":0.0000985415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003372337,"about_ca_topic_score_gemma":0.00003107391,"domain_scores_codex":[0.9987279,0.00005608735,0.0003689949,0.0003216292,0.0002794281,0.0002459159],"domain_scores_gemma":[0.9991987,0.0003130244,0.00008297856,0.0002193678,0.0000304019,0.0001555264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002683163,0.00098424,0.9907397,0.001828816,0.00006415563,0.0003145623,0.0005454984,0.00005967306,0.002310044,0.0003020813,0.00001324739,0.0001547956],"study_design_scores_gemma":[0.008926544,0.0005436355,0.9855046,0.0006792353,0.0006053278,0.000005567736,0.00004437079,0.0000168522,0.00330483,0.0001905686,0.00002035357,0.0001580753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932324,0.002310211,0.00004600689,0.00006193025,0.0002377771,0.000432793,0.00006574013,0.00002743023,0.003585688],"genre_scores_gemma":[0.9955351,0.004001201,0.0001534229,0.00002341986,0.00003606331,0.0000193302,0.00004066297,0.00001513844,0.0001756073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006243381,"threshold_uncertainty_score":0.6783314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128392917706969,"score_gpt":0.2893509076232866,"score_spread":0.2765116158525897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}