{"id":"W4417283963","doi":"10.1038/s41467-025-67090-z","title":"Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; European Commission; Infrastructures en Biologie Santé et Agronomie","keywords":"Caveolae; Cell migration; Cell; RHOA; Coupling (piping); Mechanosensitive channels; Cell membrane; Cell polarity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291394,0.0001546061,0.0001378249,0.0002287369,0.0001941328,0.0004012293,0.0001655634,0.0002299794,0.0004499972],"category_scores_gemma":[0.0002104448,0.0001787556,0.0001106188,0.0001156129,0.0002913645,0.000249924,0.0002502578,0.0003353437,0.000180983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000452348,"about_ca_system_score_gemma":0.0002928405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009573601,"about_ca_topic_score_gemma":0.001626561,"domain_scores_codex":[0.9998499,0.00001903394,0.000006545937,0.00003211875,0.00004801918,0.00004437792],"domain_scores_gemma":[0.999929,0.00001111324,0.00002157916,0.000007075152,0.00001297305,0.00001827775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003383248,0.000005640892,0.0004040744,0.00001545248,0.000003120221,0.00004190055,0.00001077283,0.0001944299,0.9965233,0.0004717873,0.0000462518,0.002249574],"study_design_scores_gemma":[0.00003717311,0.0001156144,0.06079352,0.00001858922,0.0000203644,0.0006377827,0.0001200469,0.01198663,0.9187248,0.001398326,0.006120475,0.00002670914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840343,0.004562509,0.007607617,0.0003849454,0.00002618505,0.00001326942,0.0001208097,0.000128714,0.003121682],"genre_scores_gemma":[0.9977202,0.000675751,0.0008497094,0.00003064546,0.000007263924,0.000007573648,0.00003143798,0.000008520943,0.0006689448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009573601,"threshold_uncertainty_score":0.00328207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006049720281308408,"score_gpt":0.2570489103403119,"score_spread":0.2509991900590035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}