{"id":"W4417283963","doi":"10.1038/s41467-025-67090-z","title":"Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; European Commission; Infrastructures en Biologie Santé et Agronomie","keywords":"Caveolae; Cell migration; Cell; RHOA; Coupling (piping); Mechanosensitive channels; Cell membrane; Cell polarity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383412,0.00007812848,0.00009055642,0.00005562646,0.0001868046,0.00002145576,0.0001244337,0.0002286502,9.920832e-7],"category_scores_gemma":[0.00009007591,0.00008185136,0.00002721847,0.0001130132,0.0001131172,0.00000626714,0.0001924275,0.0002010735,1.188746e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006877424,"about_ca_system_score_gemma":0.00006452113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009852994,"about_ca_topic_score_gemma":0.001197992,"domain_scores_codex":[0.9995614,0.00002169784,0.0001414788,0.0001517024,0.00005475355,0.00006894158],"domain_scores_gemma":[0.9992797,0.00004382661,0.00007418324,0.0004062946,0.0001717494,0.00002418573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001877542,0.00005085877,0.01406872,0.0000431725,0.00002588446,8.801546e-8,0.00005710684,0.0000095545,0.983143,0.001753173,0.0001810902,0.0006486157],"study_design_scores_gemma":[0.0002564472,0.00002980356,0.01740444,0.0000378127,0.00004116047,0.000005847794,0.0001266659,0.001649916,0.9691833,0.000703639,0.0104496,0.0001113372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648395,0.03250183,0.0007296143,0.001099353,0.00006140375,0.0001025928,0.00001612564,0.00001073,0.0006389176],"genre_scores_gemma":[0.9943162,0.002149342,0.002909421,0.00009408126,0.0000233659,0.000003835181,0.0002393664,0.000005950935,0.0002584063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03035248,"threshold_uncertainty_score":0.3337802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006049720281308408,"score_gpt":0.2570489103403119,"score_spread":0.2509991900590035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}