{"id":"W4417286452","doi":"10.1007/s00266-025-05498-0","title":"When Genes Meet Gels: Computational Immunogenetics of Dermal Fillers and Stratified Risk of Immune and Fibrotic Reactions across Compositions and Genotypes","year":2025,"lang":"en","type":"article","venue":"Aesthetic Plastic Surgery","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Positive Living Society of British Columbia; University of British Columbia; SKiN Health","funders":"","keywords":"Immunogenetics; Immune system; Genotype; Gene; Otorhinolaryngology; Disease; Table (database)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001697247,0.00012749,0.000360055,0.0001393672,0.0001331507,0.0000143132,0.00002699956,0.00007318064,0.00001218184],"category_scores_gemma":[0.0002370553,0.0001211788,0.00006099779,0.0001284122,0.0004555324,0.00003870556,0.00003704883,0.00007466035,5.033901e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008143546,"about_ca_system_score_gemma":0.0001419365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00016639,"about_ca_topic_score_gemma":0.00002735272,"domain_scores_codex":[0.999046,0.00006024037,0.0004390715,0.000173688,0.0001193391,0.0001616742],"domain_scores_gemma":[0.9978428,0.001713725,0.0001380029,0.000126544,0.0001013264,0.0000776359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001649289,0.0009625319,0.8883651,0.002444639,0.001201602,0.00004883316,0.003759795,0.01025776,0.03463085,0.004958452,0.0008897283,0.05083141],"study_design_scores_gemma":[0.001696371,0.000188543,0.9812485,0.0005574948,0.000458143,0.0002686835,0.001301598,0.008440782,0.002228579,0.003218023,0.0001867782,0.0002064804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934378,0.004149572,0.001699015,0.0002575277,0.00009870937,0.0001532308,0.00009773458,0.00001536146,0.00009100536],"genre_scores_gemma":[0.9977705,0.0007723715,0.001334441,0.00002624151,0.000005360523,0.000007985825,0.00004948715,0.000009181784,0.00002436617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09288342,"threshold_uncertainty_score":0.4941529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102397306796191,"score_gpt":0.2455393470074588,"score_spread":0.2352996163278397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}