{"id":"W4417286886","doi":"10.1248/bpb.b25-00265","title":"Effect of Probiotics on Immunosuppressive Drug Pharmacokinetics: Interaction between &lt;i&gt;Bacillus subtilis&lt;/i&gt; and Tacrolimus in Mice","year":2025,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Japan Research Foundation for Clinical Pharmacology","keywords":"Tacrolimus; Pharmacokinetics; Drug; Adverse effect; Dosing; Bacillus subtilis; Drug interaction; Everolimus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004042273,0.0006516038,0.0007680572,0.0003900176,0.0001483416,0.0003321261,0.0002936647,0.000572724,0.0009174563],"category_scores_gemma":[0.0002369999,0.0003259118,0.0006253166,0.0002687664,0.0003460452,0.0004371708,0.0001963017,0.001190396,0.0002798241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002461101,"about_ca_system_score_gemma":0.0004215934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009079298,"about_ca_topic_score_gemma":0.001178063,"domain_scores_codex":[0.9995238,0.0001131928,0.00004529931,0.0000841558,0.0001194328,0.0001141985],"domain_scores_gemma":[0.9996601,0.00004689693,0.0001121457,0.00003675766,0.00003128308,0.000112723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002151293,0.000775088,0.0003988801,0.00008134819,0.00002842006,0.00004791718,0.00002467579,0.0001606212,0.992391,0.00004701001,0.00007279136,0.003820892],"study_design_scores_gemma":[0.0001519289,0.01072227,0.00608677,0.00001506264,0.00009826738,0.0001241181,0.00004207783,0.001779159,0.9794836,0.00004094699,0.001436275,0.00001948975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944596,0.001949434,0.001692308,0.0002752011,0.00009463504,0.00004451546,0.0003886803,0.0001237877,0.0009719033],"genre_scores_gemma":[0.9906682,0.001838609,0.003389561,0.0002464276,0.00004145582,0.0001159134,0.0005032254,0.00004524523,0.003151256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009174563,"threshold_uncertainty_score":0.003069222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455624531587665,"score_gpt":0.3150068358702063,"score_spread":0.3004505905543297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}