{"id":"W4417286886","doi":"10.1248/bpb.b25-00265","title":"Effect of Probiotics on Immunosuppressive Drug Pharmacokinetics: Interaction between <i>Bacillus subtilis</i> and Tacrolimus in Mice","year":2025,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Japan Research Foundation for Clinical Pharmacology","keywords":"Tacrolimus; Pharmacokinetics; Drug; Adverse effect; Dosing; Bacillus subtilis; Drug interaction; Everolimus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005100313,0.0002795264,0.0004084078,0.00008067961,0.00007988401,0.00002095082,0.0001563732,0.0002875816,0.00009780577],"category_scores_gemma":[0.0001675436,0.0002053081,0.00008189788,0.000106935,0.0003237035,0.000002677781,0.0002319259,0.0003226421,0.00001370048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000210741,"about_ca_system_score_gemma":0.0000239406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004517091,"about_ca_topic_score_gemma":0.000002433818,"domain_scores_codex":[0.9981585,0.0004663016,0.0004097762,0.0005180092,0.00007469918,0.0003727456],"domain_scores_gemma":[0.9992157,0.0003617802,0.00009471954,0.0001390313,0.00005078113,0.0001379543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002056155,0.0001489406,0.005377661,0.0002526313,0.00006504997,0.000006445577,0.00003187015,0.000005545352,0.9762712,0.0001238341,0.001751908,0.01390882],"study_design_scores_gemma":[0.003037135,0.001733119,0.01647403,0.0001555606,0.00008148248,0.00001260517,0.00001239493,0.00005208514,0.6334824,0.00003154654,0.344652,0.0002756397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991905,0.004890669,0.00002211437,0.001373138,0.0001675772,0.0005446361,0.00007975894,0.00001201085,0.001005082],"genre_scores_gemma":[0.9952494,0.00360756,0.00007513244,0.0005795662,0.0001153231,0.00002035722,0.00009654527,0.00001028488,0.0002458297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3429001,"threshold_uncertainty_score":0.8372223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455624531587665,"score_gpt":0.3150068358702063,"score_spread":0.3004505905543297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}