{"id":"W4417289733","doi":"10.1007/s13555-025-01583-z","title":"Summary of Research: Apremilast in Japanese Patients with Palmoplantar Pustulosis: A Randomized, Phase 3 Trial","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Amgen","keywords":"Apremilast; Placebo; Palmoplantar pustulosis; Randomized controlled trial; Quality of life (healthcare); Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005397695,0.0009563544,0.002160346,0.0004484458,0.0006667532,0.001501559,0.0007696204,0.002375794,0.006535796],"category_scores_gemma":[0.003153225,0.0004875935,0.003345137,0.0006348118,0.0005215582,0.0007800266,0.0002854695,0.002063196,0.001081005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005915482,"about_ca_system_score_gemma":0.002760371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008770628,"about_ca_topic_score_gemma":0.002775072,"domain_scores_codex":[0.9985185,0.0008807932,0.0001926751,0.0001305263,0.0001457411,0.0001317242],"domain_scores_gemma":[0.9982768,0.0005243086,0.0004730184,0.00008829021,0.0002492018,0.0003882888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.746223,0.009508582,0.003587091,0.0232164,0.01160865,0.000441702,0.0003330627,0.0006747154,0.01791852,0.000699917,0.01786796,0.1679204],"study_design_scores_gemma":[0.907193,0.07046635,0.004226971,0.00114052,0.006134728,0.0001592632,0.0000664773,0.000276461,0.001131662,0.0003210218,0.008843646,0.00003996263],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6320829,0.2279281,0.006669605,0.02164037,0.005300514,0.06394558,0.01429826,0.0009666532,0.02716814],"genre_scores_gemma":[0.8142058,0.08235117,0.01195471,0.02946429,0.005790948,0.03592215,0.008819003,0.0001525636,0.01133922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006535796,"threshold_uncertainty_score":0.02854609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237539882915485,"score_gpt":0.2986026229296635,"score_spread":0.274848634638115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}