{"id":"W4417295603","doi":"10.1186/s13024-025-00917-x","title":"Targeted deletion of EMMPRIN in microglia/macrophages mitigates neuronal death in intracerebral hemorrhage","year":2025,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Hotchkiss Brain Institute; Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Neurotoxicity; Intracerebral hemorrhage; Microglia; Matrix metalloproteinase; Gene knockdown; Inflammation; Neurogenesis; Stroke (engine)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601244,0.0001810856,0.0001674053,0.0001626502,0.00002839825,0.00002281686,0.0001779801,0.0001337913,0.000009934322],"category_scores_gemma":[0.0002017863,0.0002145361,0.00007990462,0.0002599086,0.00004624732,0.000007362669,0.00008943464,0.0001309699,0.000002227274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002639906,"about_ca_system_score_gemma":0.0001079168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004635515,"about_ca_topic_score_gemma":0.00006116754,"domain_scores_codex":[0.9985706,0.0002272667,0.0003850643,0.0004579447,0.0001340074,0.0002250861],"domain_scores_gemma":[0.99948,0.00001133196,0.00008211602,0.0003154208,0.00007032679,0.00004081413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009066915,0.0001385129,0.01706375,0.00004362816,0.000008005451,0.00004716873,0.00001508253,0.01073641,0.9708016,0.0002538543,0.00005918921,0.000742146],"study_design_scores_gemma":[0.0007680026,0.0000878693,0.02417411,0.00002254391,0.00001206945,0.000003865031,0.000005732639,0.003462688,0.9711375,0.0001250761,0.00005585182,0.0001446461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932843,0.0008186768,0.005136058,0.0001918576,0.0001667623,0.0002744012,0.00002091022,0.00001349106,0.00009355216],"genre_scores_gemma":[0.9975359,0.00002171922,0.001482715,0.0005309001,0.00003468468,0.00003976333,0.0002594625,0.0000239444,0.0000709405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00727372,"threshold_uncertainty_score":0.874853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005596010443765161,"score_gpt":0.237208321910945,"score_spread":0.2316123114671798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}