{"id":"W4417297358","doi":"10.1021/acsinfecdis.5c00736","title":"Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in <i> <i>Enterococcus faecium</i> </i> Septicemic Peritonitis Mouse Model While Sparing the Microbiome","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada); Collège Boréal","funders":"Horizon 2020 Framework Programme; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue Institute for Drug Discovery","keywords":"Acetazolamide; In vivo; Carbonic anhydrase; Antibiotics; Microbiome; Gut microbiome; Gut flora; Gastrointestinal tract","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008180524,0.0002540993,0.000189853,0.0001149427,0.0002068532,0.0001259259,0.0001657974,0.0001638398,0.00002351319],"category_scores_gemma":[0.00008920742,0.0002271629,0.0001401085,0.0002289495,0.0001435426,0.00002163901,0.0001561885,0.000175939,0.00001394404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008447726,"about_ca_system_score_gemma":0.0001938499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001127676,"about_ca_topic_score_gemma":0.0004946283,"domain_scores_codex":[0.9987205,0.00009439755,0.0003079113,0.0004438899,0.00009371278,0.0003396038],"domain_scores_gemma":[0.9993356,0.00003468601,0.00008279122,0.0003862709,0.00007601157,0.00008464937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001493257,0.0004244543,0.01471559,0.0000355263,0.0000507707,0.000003392474,0.00003659923,0.002137453,0.974514,0.00004536222,0.007616676,0.0002708167],"study_design_scores_gemma":[0.004107685,0.0002858916,0.003008675,0.0001475446,0.000156369,0.00002590691,0.0001375761,0.0008096235,0.9824355,0.00008928714,0.008219104,0.0005768584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959989,0.0005646025,0.0002008771,0.0001349651,0.0004935565,0.000393128,0.0001866821,0.00007494115,0.001952401],"genre_scores_gemma":[0.997207,0.0002525214,0.00001346607,0.001009769,0.0002861954,0.0001071917,0.0004065373,0.00002837188,0.0006888912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01170691,"threshold_uncertainty_score":0.9263436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006034143450997236,"score_gpt":0.2253233565567682,"score_spread":0.219289213105771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}