{"id":"W4417297358","doi":"10.1021/acsinfecdis.5c00736","title":"Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in <i> <i>Enterococcus faecium</i> </i> Septicemic Peritonitis Mouse Model While Sparing the Microbiome","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada); Collège Boréal","funders":"Horizon 2020 Framework Programme; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue Institute for Drug Discovery","keywords":"Acetazolamide; In vivo; Carbonic anhydrase; Antibiotics; Microbiome; Gut microbiome; Gut flora; Gastrointestinal tract","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189226,0.0003408075,0.0002759897,0.0002389366,0.0001084065,0.0001970117,0.0002103044,0.0003798536,0.001715598],"category_scores_gemma":[0.0001011283,0.00009735054,0.0002922642,0.0001532779,0.0001920293,0.0001877503,0.0001072352,0.0008781395,0.0003503332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001955537,"about_ca_system_score_gemma":0.000332807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212434,"about_ca_topic_score_gemma":0.002200817,"domain_scores_codex":[0.9998875,0.00001198916,0.00001049969,0.00001992772,0.00004099019,0.00002907885],"domain_scores_gemma":[0.9999272,0.000007601194,0.00002348675,0.000005326019,0.000009683101,0.00002679591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004335503,0.0001280205,0.0002465658,0.0001382161,0.00001298902,0.00006373612,0.000008354988,0.0001235829,0.9951309,0.00007078155,0.000499276,0.003143984],"study_design_scores_gemma":[0.00004963699,0.001850937,0.003742187,0.00001803583,0.00002982567,0.0002222159,0.00003091204,0.0009277251,0.9883376,0.00004401819,0.004736172,0.00001082191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982797,0.004994347,0.00297211,0.0006909398,0.0001783894,0.00007090293,0.002430937,0.0004491801,0.005416139],"genre_scores_gemma":[0.9816768,0.004368272,0.0041866,0.0004364045,0.00002335474,0.00008446198,0.003020317,0.00004724275,0.006156524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715598,"threshold_uncertainty_score":0.005739272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006034143450997236,"score_gpt":0.2253233565567682,"score_spread":0.219289213105771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}