{"id":"W4417304786","doi":"10.1016/j.sbi.2025.103197","title":"Next-generation predictors of protein phase behavior","year":2025,"lang":"en","type":"article","venue":"Current Opinion in Structural Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Michael Smith Health Research BC; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Benchmarking; Inference; Phase (matter); Protein–protein interaction; Current (fluid); Computational model","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009886378,0.0007030871,0.0008403583,0.001863984,0.0003754003,0.0009284698,0.0006613,0.000787053,0.003660386],"category_scores_gemma":[0.004376125,0.000394899,0.0006813785,0.001264833,0.0003858805,0.001709659,0.0007458907,0.001457493,0.00235882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000322077,"about_ca_system_score_gemma":0.0003309213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008880502,"about_ca_topic_score_gemma":0.002436086,"domain_scores_codex":[0.9997682,0.00004944247,0.000008955305,0.0000904609,0.0000479952,0.00003491259],"domain_scores_gemma":[0.9971319,0.001528523,0.0005345282,0.0003493041,0.0002936287,0.0001620834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003401785,0.00135617,0.4080501,0.001060238,0.001439562,0.0006690047,0.0002638394,0.1462596,0.1089953,0.01399428,0.0248712,0.2896389],"study_design_scores_gemma":[0.00008153069,0.0001799438,0.054145,0.00006516468,0.0002088952,0.0004299522,0.00005473232,0.9050087,0.0145111,0.01979164,0.005446941,0.00007636752],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7700986,0.006784536,0.1943289,0.00105744,0.0002933492,0.00009549598,0.01422002,0.005527669,0.007594125],"genre_scores_gemma":[0.9680483,0.0009649507,0.02171522,0.0001575438,0.0001953077,0.00007972612,0.007382355,0.0002189118,0.001237615],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003660386,"threshold_uncertainty_score":0.01224518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05982724372840828,"score_gpt":0.3981631880485239,"score_spread":0.3383359443201156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}