{"id":"W4417304907","doi":"10.1128/mbio.02119-25","title":"A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam; ZonMw","keywords":"Cell envelope; Virulence; Lipoarabinomannan; Periplasmic space; Biogenesis; Bacterial outer membrane; ESCRT; Virulence factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003357062,0.00009442268,0.0002615172,0.0001284872,0.00004474563,0.00001655175,0.00005706781,0.0001231768,0.0000515862],"category_scores_gemma":[0.0004969036,0.00008069172,0.00004655611,0.00016397,0.00002901875,0.0000309155,0.00005091586,0.0001079861,0.00001050231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004558218,"about_ca_system_score_gemma":0.0002452331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002873976,"about_ca_topic_score_gemma":0.0007372659,"domain_scores_codex":[0.9991317,0.00005384546,0.0002103038,0.0002360467,0.00005716362,0.0003109518],"domain_scores_gemma":[0.9995048,0.0001723176,0.00002585363,0.0001395717,0.00002659835,0.0001308754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001038723,0.0001339076,0.2026809,0.0004017861,0.00006794805,0.00001608762,0.0003508898,0.000001475067,0.651559,0.000529785,0.01435403,0.1288654],"study_design_scores_gemma":[0.007854904,0.001122786,0.5909486,0.0003032981,0.00008419781,0.00001894872,0.0003761223,0.000588517,0.2694573,0.002423228,0.1265076,0.0003145495],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905267,0.0007249921,0.0004473948,0.005010335,0.00008740965,0.0006115779,0.00001228907,0.00002717308,0.002552075],"genre_scores_gemma":[0.9852581,0.0001478812,0.01074376,0.000818577,0.0002881375,0.00008956816,0.00003596982,0.00001179872,0.002606183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3882676,"threshold_uncertainty_score":0.4344611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978020287902369,"score_gpt":0.310514242991609,"score_spread":0.2907340401125852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}