{"id":"W4417304907","doi":"10.1128/mbio.02119-25","title":"A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam; ZonMw","keywords":"Cell envelope; Virulence; Lipoarabinomannan; Periplasmic space; Biogenesis; Bacterial outer membrane; ESCRT; Virulence factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183361,0.0003598186,0.0002809624,0.000168572,0.0002827845,0.0006352004,0.0001701679,0.0005062246,0.0008294497],"category_scores_gemma":[0.00009795815,0.0001681848,0.0002644105,0.00009030691,0.0003156008,0.000394827,0.0005137966,0.000506712,0.0004350971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002748142,"about_ca_system_score_gemma":0.0001954085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002155937,"about_ca_topic_score_gemma":0.0002303586,"domain_scores_codex":[0.99989,0.00001270975,0.00000636942,0.00003525926,0.000029806,0.00002594366],"domain_scores_gemma":[0.9999214,0.000007630378,0.00002066341,0.000007498415,0.00001383059,0.00002895823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008500337,0.00001217071,0.0006215069,0.0000327505,0.000002903592,0.0001430116,0.00002088918,0.00005043228,0.9974934,0.0002813869,0.00005434107,0.001202355],"study_design_scores_gemma":[0.00004252886,0.0003197288,0.0356714,0.00005158483,0.00003346505,0.001416516,0.0002758733,0.008964917,0.9367874,0.001038813,0.0153714,0.00002631255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801518,0.005197156,0.01112722,0.0005231338,0.00007381827,0.00002270559,0.0002997305,0.000280746,0.002323652],"genre_scores_gemma":[0.9927433,0.0006594689,0.003968035,0.0001133944,0.00001519604,0.00001411698,0.000262523,0.00003181682,0.002192227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008294497,"threshold_uncertainty_score":0.002774835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978020287902369,"score_gpt":0.310514242991609,"score_spread":0.2907340401125852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}