{"id":"W4417308520","doi":"10.1093/noajnl/vdaf258","title":"Proteomics in IDH-mutated diffuse lower-grade glioma: a scoping review","year":2025,"lang":"en","type":"review","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Proteome; Proteomics; Energy metabolism; Citric acid cycle; Metabolomics; Precision medicine; Dependency (UML)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003268557,0.0007962637,0.005001246,0.0006758418,0.0001017337,0.00001944326,0.0003245114,0.0005279284,0.00006346741],"category_scores_gemma":[0.001341882,0.0006021817,0.0006961209,0.001526498,0.0001720866,0.0001274265,0.0002061834,0.0009574116,0.00008531581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005065632,"about_ca_system_score_gemma":0.001659911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009416335,"about_ca_topic_score_gemma":0.00009614674,"domain_scores_codex":[0.9958321,0.0005884407,0.001485741,0.0010994,0.0002839676,0.0007103257],"domain_scores_gemma":[0.9964673,0.001753225,0.0007546956,0.0007391151,0.00009087946,0.0001947986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000556113,0.002146105,0.0001223092,0.3478558,0.0001657845,0.007152665,0.00001191163,0.000001427441,0.00002716381,0.00003704358,0.0006225892,0.6418016],"study_design_scores_gemma":[0.002011989,0.0005801828,0.000006469013,0.4695327,0.001785461,0.0007438082,0.00000281994,8.83502e-7,0.00005352356,0.00002434482,0.5249757,0.0002820455],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001399076,0.986578,0.000004897377,0.001093867,0.0009339746,0.01052238,0.00003560361,0.0001253925,0.0005660139],"genre_scores_gemma":[0.0000110763,0.9928057,0.0005999956,0.001190188,0.0001398571,0.005006333,0.0001421291,0.00007173682,0.00003301504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6415195,"threshold_uncertainty_score":0.999643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03957614794320865,"score_gpt":0.4052556704433768,"score_spread":0.3656795225001682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}