{"id":"W4417311889","doi":"10.1038/s41523-025-00874-0","title":"The role of circulating tumor cell-associated genes in the progression of estrogen receptor-positive breast cancer","year":2025,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Ministry of Health and Long-Term Care; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Breast cancer; Estrogen receptor; Circulating tumor cell; Fluorescence in situ hybridization; Estrogen; Stage (stratigraphy); Disease; Proportional hazards model; Adjuvant therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003853892,0.0001725219,0.0003765495,0.00007368489,0.0001181083,0.00001554463,0.0001928656,0.00006797879,0.0001705092],"category_scores_gemma":[0.00001742866,0.0001010844,0.0001531149,0.0005862123,0.0001493532,0.00004691198,0.00005836429,0.0002103252,0.000001062166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002385558,"about_ca_system_score_gemma":0.0006250736,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007593842,"about_ca_topic_score_gemma":0.000686342,"domain_scores_codex":[0.9985111,0.0001329932,0.0004106981,0.0002464609,0.0003872809,0.0003114529],"domain_scores_gemma":[0.9989051,0.000118814,0.000324763,0.0002845563,0.0003168622,0.00004993785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008028818,0.0003407998,0.4223598,0.0002076631,0.0002703098,0.000006126176,0.001041229,0.0001003989,0.101756,0.0002052112,0.000556739,0.4723529],"study_design_scores_gemma":[0.002951475,0.0001000631,0.8409961,0.002888882,0.0005864231,0.00005494532,0.003367332,0.000388079,0.1420504,0.00009515398,0.006282408,0.0002387492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671906,0.02382693,0.000004985697,0.003338463,0.0003447792,0.000805073,0.0007402986,0.00001865337,0.003730245],"genre_scores_gemma":[0.9982157,0.0009668817,0.00004520918,0.0002179349,0.000157777,0.0002280935,0.00001571696,0.00001955596,0.0001330978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4721142,"threshold_uncertainty_score":0.9990147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00607237937998069,"score_gpt":0.2828771518055007,"score_spread":0.27680477242552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}