{"id":"W4417315601","doi":"10.1021/acsomega.5c09235","title":"Simultaneous Determination of Lyso-Gb1 and Lyso-Gb3 in Plasma Using Salt-Assisted Liquid–Liquid Extraction Combined with LC–MS/MS","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Extraction (chemistry); Matrix (chemical analysis); Reproducibility; Human plasma; Ammonium acetate; Detection limit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007006637,0.0005819122,0.0003148129,0.0005824624,0.0002445518,0.0003475098,0.0003223065,0.000598442,0.001202684],"category_scores_gemma":[0.000629281,0.0002075611,0.0003158365,0.0003750531,0.0004274419,0.0003208829,0.0004223277,0.0004420748,0.0008088629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157584,"about_ca_system_score_gemma":0.0003686104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003807863,"about_ca_topic_score_gemma":0.0008362134,"domain_scores_codex":[0.9993604,0.0001378479,0.0000450291,0.0001629589,0.0002443209,0.00004944041],"domain_scores_gemma":[0.9997894,0.00006610182,0.00004901442,0.00002014925,0.0000602871,0.00001500078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002676998,0.00002813184,0.00159399,0.00009833541,0.00002807816,0.00007997387,0.00003205363,0.0001208523,0.9895293,0.00005696093,0.0001606504,0.008004118],"study_design_scores_gemma":[0.00003363803,0.0003626212,0.01021252,0.00002146415,0.00004825843,0.00084168,0.00003574447,0.004002247,0.9819412,0.000183411,0.002284145,0.00003305303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8246964,0.004728702,0.1645576,0.0004122274,0.00009736434,0.000358521,0.001535431,0.001058066,0.002555809],"genre_scores_gemma":[0.8520932,0.002279545,0.1387533,0.0006122951,0.00005169108,0.0006211267,0.001266425,0.000106712,0.004215657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202684,"threshold_uncertainty_score":0.004023314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995393531661213,"score_gpt":0.318796395458287,"score_spread":0.2988424601416748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}