{"id":"W4417319335","doi":"10.1096/fj.202503348rr","title":"Loss of <scp>RNASEK</scp> Terminates Egg Cylinder Development by Impairing Lysosomal Function Associated With V‐ <scp>ATPase</scp> in Mouse","year":2025,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Key Research and Development Program of China; Key Programme; National Natural Science Foundation of China; Ministry of Science and Technology","keywords":"Embryo; Autophagy; Protein subunit; Knockout mouse; Senescence; Function (biology); Loss function; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003381785,0.0006203803,0.0003289939,0.0008463024,0.0002551647,0.0004954368,0.0004046716,0.000806869,0.002549166],"category_scores_gemma":[0.0002008069,0.0003776689,0.0004779513,0.0002191011,0.0007246513,0.0004676005,0.0003460271,0.001116315,0.001047117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005484575,"about_ca_system_score_gemma":0.000433454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000753,"about_ca_topic_score_gemma":0.001561299,"domain_scores_codex":[0.9996592,0.00004399571,0.00005890899,0.00007668351,0.00008293441,0.00007831192],"domain_scores_gemma":[0.9994349,0.00007992252,0.0002229871,0.00006121436,0.00003459548,0.0001663243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021926,0.00001924617,0.0001336748,0.00002656088,0.000005891543,0.0001051601,0.0000126316,0.0000538742,0.9988769,0.0001999571,0.00002821174,0.000435724],"study_design_scores_gemma":[0.00001912155,0.000165102,0.002781475,0.000009720226,0.00001600676,0.000377494,0.00003147624,0.0006177021,0.9941011,0.00007591358,0.001798891,0.000006057049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989783,0.001448448,0.00478418,0.0002262975,0.00004838283,0.00004690936,0.00154169,0.0003610507,0.001760052],"genre_scores_gemma":[0.9838969,0.0008587016,0.003068714,0.00008875933,0.00001465618,0.00007540172,0.001228531,0.000182623,0.01058578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002549166,"threshold_uncertainty_score":0.008527815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009898715751990377,"score_gpt":0.2527531644155496,"score_spread":0.2428544486635592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}