{"id":"W4417321217","doi":"10.1186/s13063-025-09345-0","title":"Fecal microbiota transplantation to reduce immune activation in ART-treated people with HIV with low CD4/CD8 ratio: protocol for the single-blind, randomized, placebo-controlled Gutsy study (CIHR/CTN PT038)","year":2025,"lang":"en","type":"article","venue":"Trials","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; McGill University Health Centre; Lawson Health Research Institute; Western University; Centre Hospitalier de l’Université de Montréal; HIV Legal Network","funders":"Fonds de Recherche du Québec - Santé; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Human immunodeficiency virus (HIV); Fecal bacteriotherapy; Immune system; Feces; Transplantation; Protocol (science); Microbiome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004673596,0.0004031452,0.002112203,0.0004817521,0.0002271899,0.0001662779,0.0002107756,0.0001487344,0.0001259436],"category_scores_gemma":[0.002131101,0.0002183904,0.0002712847,0.001065255,0.00008830227,0.0001114926,0.00002629329,0.0003332543,0.000022514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830205,"about_ca_system_score_gemma":0.0006422462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002567021,"about_ca_topic_score_gemma":0.0006754622,"domain_scores_codex":[0.9958339,0.001157111,0.0014139,0.0005924522,0.0005253113,0.0004773086],"domain_scores_gemma":[0.9935559,0.004987806,0.0003769822,0.0005368388,0.0004381768,0.0001043014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.743129,0.001506118,0.00023118,0.0002276479,0.0006651806,0.00001032223,0.0008405614,0.0003618943,0.2515643,0.00001420459,0.0006673848,0.0007822433],"study_design_scores_gemma":[0.668658,0.001833437,0.0006406044,0.0007392025,0.0008284756,0.000009083476,0.0007103464,0.0003635911,0.3258302,0.000003480395,0.0001885254,0.0001950066],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5959702,0.00001198253,0.003019222,0.003610173,0.00004110792,0.3969731,0.00002300444,0.00005268203,0.0002985489],"genre_scores_gemma":[0.647977,0.000004839666,0.0001383579,0.00007398744,0.0001431575,0.3489168,0.0001117265,0.00003659393,0.002597574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07447092,"threshold_uncertainty_score":0.8905703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05642504664135313,"score_gpt":0.3845318580873807,"score_spread":0.3281068114460275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}