{"id":"W4417321217","doi":"10.1186/s13063-025-09345-0","title":"Fecal microbiota transplantation to reduce immune activation in ART-treated people with HIV with low CD4/CD8 ratio: protocol for the single-blind, randomized, placebo-controlled Gutsy study (CIHR/CTN PT038)","year":2025,"lang":"en","type":"article","venue":"Trials","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; McGill University Health Centre; Lawson Health Research Institute; Western University; Centre Hospitalier de l’Université de Montréal; HIV Legal Network","funders":"Fonds de Recherche du Québec - Santé; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Human immunodeficiency virus (HIV); Fecal bacteriotherapy; Immune system; Feces; Transplantation; Protocol (science); Microbiome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01009265,0.00520233,0.008582394,0.002003652,0.003138726,0.002440505,0.002932779,0.00742328,0.04761437],"category_scores_gemma":[0.008711228,0.002607104,0.003434105,0.001649445,0.002818806,0.002468155,0.001727711,0.006370135,0.007739181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002115177,"about_ca_system_score_gemma":0.007873164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002179317,"about_ca_topic_score_gemma":0.003708946,"domain_scores_codex":[0.992968,0.003779463,0.0007330083,0.0008848074,0.0005519958,0.001082763],"domain_scores_gemma":[0.9952464,0.0008819465,0.00102547,0.0005960567,0.0009293401,0.001320919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.959805,0.01876886,0.000272014,0.003239384,0.0004498624,0.00006894936,0.00009491837,0.000409563,0.002084296,0.000466601,0.003695109,0.01064537],"study_design_scores_gemma":[0.9635959,0.02958421,0.0006975296,0.0003583519,0.0002259716,0.00001848576,0.0000251833,0.000275696,0.0003992597,0.0003101177,0.004476269,0.00003306171],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01915456,0.0007491109,0.001370181,0.0005166709,0.0006510164,0.9734123,0.00218614,0.0002535398,0.001706507],"genre_scores_gemma":[0.01927313,0.0005658186,0.00293669,0.0005774485,0.0002650808,0.9745272,0.0004291879,0.00002208959,0.001403449],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04761437,"threshold_uncertainty_score":0.1592859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05642504664135313,"score_gpt":0.3845318580873807,"score_spread":0.3281068114460275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}