{"id":"W4417329339","doi":"10.1007/s40744-025-00812-3","title":"Influence of Biological Sex on Participant Characteristics, Guselkumab Efficacy and Radiographic Progression in Active Psoriatic Arthritis: Post Hoc Analysis of Three Randomized Trials","year":2025,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Women's College Hospital; Toronto Western Hospital","funders":"Johnson and Johnson; Swedish Orphan Biovitrum; University of Pennsylvania; Biogen; Gilead Sciences; Amgen; Pfizer; Yale University; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Post-hoc analysis; Post hoc; Randomized controlled trial; Clinical trial; Cohort study; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000814478,0.0001651648,0.002776387,0.0004713616,0.00005557241,0.000004162322,0.00003776202,0.000143714,0.00001356838],"category_scores_gemma":[0.0009887266,0.0001033753,0.0001837231,0.0004438539,0.0005155504,0.00002235713,0.00002223222,0.000102392,2.394908e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006624109,"about_ca_system_score_gemma":0.00003201162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000911536,"about_ca_topic_score_gemma":0.00004218757,"domain_scores_codex":[0.9981781,0.0004881394,0.000816372,0.0002603969,0.00008391032,0.0001731151],"domain_scores_gemma":[0.9973042,0.002062106,0.0003571433,0.0001597886,0.0000748543,0.00004188104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.202728,0.001052208,0.5138698,0.00006587125,0.009314681,0.00002989008,0.001149961,0.000003862293,0.0003526513,0.002372206,0.000001846463,0.2690591],"study_design_scores_gemma":[0.1463243,0.001494859,0.8492427,0.0007990542,0.0007938882,0.000009721995,0.000104934,0.00005884939,0.0005388646,0.0005484725,0.000007392516,0.00007692747],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729323,0.02578607,0.000005503234,0.0002400964,0.00003996079,0.0009415298,0.00003016853,0.00001168453,0.00001262473],"genre_scores_gemma":[0.8894953,0.1102844,0.00003884855,0.00005043692,0.000002297124,0.0001008455,0.0000226573,0.000003893614,0.000001374606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.335373,"threshold_uncertainty_score":0.4215521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0397297530335101,"score_gpt":0.3453772150662983,"score_spread":0.3056474620327881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}