{"id":"W4417331595","doi":"10.7554/elife.109534","title":"Global molecular landscape of early MASLD progression in human obesity","year":2025,"lang":"en","type":"article","venue":"eLife","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; Science for Life Laboratory; Vetenskapsrådet; IngaBritt och Arne Lundbergs Forskningsstiftelse; Robert Bosch Stiftung; Cancerfonden; Stiftelsen för Strategisk Forskning; Agency for Science, Technology and Research; Knut och Alice Wallenbergs Stiftelse; National Medical Research Council; European Federation of Pharmaceutical Industries and Associations; National Research Foundation; European Commission; Novo Nordisk; Diamond Light Source; McGill University","keywords":"Metabolomics; Steatosis; Transcriptome; Fatty liver; Lipid metabolism; Asymptomatic; Obesity; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247786,0.0002244917,0.0002728051,0.0007435703,0.0001751175,0.0005200811,0.00009698833,0.0002054724,0.001138518],"category_scores_gemma":[0.000267929,0.0001598781,0.000280817,0.000605211,0.0001903885,0.0002296687,0.000394875,0.0003658822,0.0002247146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001950354,"about_ca_system_score_gemma":0.0001961826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008423233,"about_ca_topic_score_gemma":0.001409658,"domain_scores_codex":[0.999871,0.00002080709,0.000005856459,0.00004881381,0.00002133404,0.0000321808],"domain_scores_gemma":[0.9998796,0.00002393831,0.00005169256,0.00001004805,0.000017925,0.00001678265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002215291,0.00007955415,0.2513097,0.0005291604,0.0004949226,0.0008798488,0.0005484569,0.00236331,0.6483419,0.002198881,0.00205714,0.08898181],"study_design_scores_gemma":[0.00002285354,0.0002300553,0.9597799,0.00009736842,0.000196442,0.0009530807,0.0005469453,0.002654781,0.02238009,0.002513259,0.01058822,0.0000370124],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827778,0.006354624,0.003667166,0.0004657921,0.00001687776,0.00001772217,0.004885858,0.0001162271,0.001697983],"genre_scores_gemma":[0.9855067,0.00404403,0.003391686,0.0002405861,0.0000234206,0.00004455687,0.005091006,0.00003855197,0.001619652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138518,"threshold_uncertainty_score":0.003808677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007364254115241818,"score_gpt":0.3147327415714357,"score_spread":0.3073684874561938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}