{"id":"W4417331872","doi":"10.21203/rs.3.rs-7520834/v1","title":"Metagenomics and culturomics reveal the dual role of gut microbiome in the development of immune-related toxicities and immune checkpoint inhibitors efficacy in cancer","year":2025,"lang":"","type":"preprint","venue":"Research Square","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Seerave Foundation","keywords":"Metagenomics; Microbiome; Melanoma; Cancer; Gut flora; Colorectal cancer; Shotgun; Immune system; Bacteroides fragilis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005961654,0.0004390428,0.0005580229,0.0005531993,0.0003159094,0.001392769,0.0003257664,0.0008462726,0.001893564],"category_scores_gemma":[0.001030944,0.00030638,0.0006439197,0.0007713675,0.0003434233,0.0006501935,0.0007194949,0.001131967,0.0004451934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003417378,"about_ca_system_score_gemma":0.0003982461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009393,"about_ca_topic_score_gemma":0.001768156,"domain_scores_codex":[0.9996202,0.000064796,0.00001545721,0.0001182967,0.000121063,0.0000600675],"domain_scores_gemma":[0.9995425,0.0001049337,0.000137603,0.00009347792,0.00006321559,0.00005828727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001155826,0.0001317306,0.04987292,0.0003814901,0.0006100935,0.0001316317,0.0002638811,0.001681232,0.8948637,0.002576329,0.002109776,0.04622146],"study_design_scores_gemma":[0.00008945094,0.0008759378,0.6186126,0.0001745615,0.001085088,0.0007172924,0.0008201965,0.01635182,0.3137769,0.01335177,0.03399644,0.0001480175],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555928,0.005924165,0.01907103,0.00131426,0.0003036745,0.00003078787,0.01383706,0.0004446939,0.003481551],"genre_scores_gemma":[0.977813,0.002585063,0.0108187,0.0006441677,0.0001023053,0.00005258269,0.005635304,0.0002116235,0.002137169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001893564,"threshold_uncertainty_score":0.006334543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775382883014975,"score_gpt":0.3535821836251662,"score_spread":0.3258283547950164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}