{"id":"W4417332166","doi":"10.18609/nai.2024.044","title":"Exploring alternatives to plasmid DNA for safer, higher quality gene therapy","year":2024,"lang":"en","type":"article","venue":"Nucleic Acid Insights","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner","funders":"","keywords":"Genetic enhancement; Plasmid; Gene; DNA; Quality (philosophy)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004155068,0.0005134291,0.0006109748,0.001047364,0.0004576402,0.003595343,0.0009539279,0.003716975,0.004187013],"category_scores_gemma":[0.003402396,0.0003268824,0.0005266126,0.0007039373,0.002366353,0.004403003,0.0008460677,0.006063149,0.001507329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000990776,"about_ca_system_score_gemma":0.0009109995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005072593,"about_ca_topic_score_gemma":0.001377745,"domain_scores_codex":[0.9982973,0.0003653321,0.0001638493,0.0001576436,0.0009092161,0.00010669],"domain_scores_gemma":[0.9972167,0.001859505,0.0001974903,0.00004760129,0.000543648,0.0001351057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004988878,0.0002622548,0.0006075003,0.003598839,0.00007950512,0.001616955,0.0008751655,0.001075009,0.09322853,0.1644694,0.1672326,0.5664554],"study_design_scores_gemma":[0.00005700146,0.0003065899,0.0001327905,0.0002298162,0.00002570306,0.000882146,0.0002514897,0.000452373,0.01587954,0.01715419,0.9646011,0.00002727854],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.006387235,0.6233631,0.04962073,0.2408421,0.05795981,0.0001235871,0.00009189613,0.0002915305,0.02131997],"genre_scores_gemma":[0.05343181,0.6844435,0.04412693,0.1082029,0.04264501,0.0002220578,0.0001610211,0.0003562474,0.06641044],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004187013,"threshold_uncertainty_score":0.02197438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1377777980168223,"score_gpt":0.3288913829335071,"score_spread":0.1911135849166847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}