{"id":"W4417335139","doi":"10.1016/j.jad.2025.120877","title":"Inflammatory response to repeated subcutaneous esketamine in treatment-resistant depression: The role of baseline C-reactive protein","year":2025,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Inflammatory response; Immune system; Inflammation; Baseline (sea); Pathophysiology; C-reactive protein; Major depressive disorder; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003517232,0.0003154751,0.000512753,0.0001827311,0.0001239102,0.0002794168,0.0001522316,0.0004170998,0.0007697502],"category_scores_gemma":[0.001095641,0.0001232593,0.000204639,0.0001380711,0.0001667454,0.0001764303,0.00009052383,0.0006174431,0.0001317922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002510393,"about_ca_system_score_gemma":0.0001699884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007755099,"about_ca_topic_score_gemma":0.001124042,"domain_scores_codex":[0.9998415,0.00006619837,0.00001611664,0.00001860614,0.00003041212,0.00002729041],"domain_scores_gemma":[0.9993754,0.0001515864,0.0001994838,0.00003805974,0.00004905331,0.0001864459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1822809,0.007200957,0.5001021,0.0004421387,0.0007368419,0.006438926,0.0005359239,0.001111239,0.2109885,0.0001099834,0.0008670255,0.08918546],"study_design_scores_gemma":[0.0005862875,0.01841366,0.9720128,0.00001542626,0.000146967,0.001530667,0.0001381904,0.001553843,0.005320603,0.00003271159,0.0002323674,0.00001650033],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992633,0.0003269834,0.00008498934,0.0000346132,0.0000134386,0.00001470619,0.00003156122,0.000006383818,0.0002239976],"genre_scores_gemma":[0.9996244,0.0001044409,0.00006003052,0.00003034908,0.00002062298,0.000007067252,0.00003968737,9.046773e-7,0.0001125005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007755099,"threshold_uncertainty_score":0.002575099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005057117868870494,"score_gpt":0.2467213263750661,"score_spread":0.2416642085061956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}