{"id":"W4417340894","doi":"10.2196/76811","title":"IL-6/GP130/JAK/STAT3 Pathway Activation in Pancreatic Ductal Adenocarcinoma and Its Association With Clinical Features: Protocol for a Retrospective Cross-Sectional Study","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pancreatic ductal adenocarcinoma; Disease; Clinical pathway; Pancreatic cancer; Signal transduction; Clinical Practice; Association (psychology); Protocol (science)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003897146,0.0002285206,0.000478413,0.0005389869,0.0004529887,0.0002717976,0.0001407516,0.000264385,0.00007247264],"category_scores_gemma":[0.00325838,0.0001801813,0.0001104999,0.0009051439,0.00009638782,0.0003514392,0.0001057519,0.00166709,0.000007600268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001138559,"about_ca_system_score_gemma":0.0009700979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007011571,"about_ca_topic_score_gemma":0.0001041163,"domain_scores_codex":[0.996282,0.0006567225,0.000742927,0.0007793038,0.000997374,0.0005416028],"domain_scores_gemma":[0.9964913,0.001135555,0.0002472999,0.0003239417,0.001654785,0.0001471296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01075994,0.003088792,0.9763986,0.0005744962,0.0001518605,0.00001781185,0.0004243201,0.000001714208,0.005961785,0.0005243003,0.00188653,0.0002098681],"study_design_scores_gemma":[0.01479397,0.009692935,0.960459,0.001811551,0.000008426173,0.00001261223,0.0003814599,0.0001360079,0.005938297,0.0003776948,0.006233069,0.000154984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2926337,6.0712e-7,0.00004978026,0.0002618349,0.0000109612,0.7063317,0.00002938963,0.00004842493,0.0006335217],"genre_scores_gemma":[0.3099383,8.573955e-8,0.0001085568,0.00003403701,0.0002263172,0.687464,0.00001611651,0.00002411837,0.002188487],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01886773,"threshold_uncertainty_score":0.7347581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2328737823929902,"score_gpt":0.5776392309963851,"score_spread":0.344765448603395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}